Lipid-Related Markers and Cardiovascular Disease Prediction

E. di Angelantonio, P. Gao, L. Pennells, D. Kromhout

Research output: Contribution to journalArticleAcademicpeer-review

300 Citations (Scopus)


Context The value of assessing various emerging lipid-related markers for prediction of first cardiovascular events is debated. Objective To determine whether adding information on apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 to total cholesterol and high-density lipoprotein cholesterol (HDL-C) improves cardiovascular disease (CVD) risk prediction. Design, Setting, and Participants Individual records were available for 165 544 participants without baseline CVD in 37 prospective cohorts (calendar years of recruitment: 1968-2007) with up to 15 126 incident fatal or nonfatal CVD outcomes (10 132 CHD and 4994 stroke outcomes) during a median follow-up of 10.4 years (interquartile range, 7.6-14 years). Man Outcome Measures Discrimination of CVD outcomes and reclassification of participants across predicted 10-year risk categories of low (
Original languageEnglish
Pages (from-to)2499-2506
JournalJAMA: The Journal of the American Medical Association
Issue number23
Publication statusPublished - 2012


  • coronary-heart-disease
  • non-hdl cholesterol
  • myocardial-infarction
  • apolipoprotein-b
  • ldl cholesterol
  • a-i
  • risk
  • lipoprotein(a)
  • metaanalysis
  • prevention

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