Lipase catalyzed synthesis of aromatic esters of sugar alcohols

R. Croitoru, L.A.M. van den Broek, A.E. Frissen, C.M. Davidescu, F. Peter, C.G. Boeriu

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Commercially available lipases (Candida antarctica lipase B, Novozyme 435, Thermomyces lanuginosus lipase, and Lipozyme TL IM), as well as sol-gel immobilized lipases, have been screened for their ability to acylate regioselectively xylitol, sorbitol, and mannitol with a phenolic ester in a binary mixture of t-butanol and dimethylsulfoxide. HPLC and MALDI-TOF MS analysis revealed the exclusive formation of monoesters for all studied sugar alcohols. The lipases immobilized by the sol-gel entrapment method proved to be efficient catalysts, leading to high conversions (up to 60%) in the investigated acylation reactions. From a sequence of silane precursors with different nonhydrolyzable groups in their structure, the presence of octyl and i-butyl group was most beneficial for the catalytic activity of sol-gel entrapped lipases in the studied process.
Original languageEnglish
Pages (from-to)484-489
JournalWorld Academy of Science, Engineering and Technology
Volume76
Publication statusPublished - 2011

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