Limits to adaptation in asexual populations

Research output: Contribution to journalArticleAcademicpeer-review

62 Citations (Scopus)

Abstract

In asexual populations, the rate of adaptation is basically limited by the frequency and properties of spontaneous beneficial mutations. Hence, knowledge of these mutational properties and how they are affected by particular evolutionary conditions is a precondition for understanding the process of adaptation. Here, we address how the rate of adaptation of asexual populations is limited by its population size and mutation rate, as well as by two factors affecting the fraction of mutations that confer a benefit, i.e. the initial adaptedness of the population and the variability of the environment. These factors both influence which mutations are likely to occur, as well as the probability that they will ultimately contribute to adaptation. We attempt to separate the consequences of these basic population features in terms of their effect on the rate of adaptation by using results from evolution experiments with microorganisms
Original languageEnglish
Pages (from-to)779-788
JournalJournal of Evolutionary Biology
Volume18
Issue number4
DOIs
Publication statusPublished - 2005

Keywords

  • term experimental evolution
  • escherichia-coli
  • rna virus
  • beneficial mutations
  • bacterial-populations
  • mullers ratchet
  • mutator genes
  • fitness
  • dynamics
  • meltdown

Fingerprint

Dive into the research topics of 'Limits to adaptation in asexual populations'. Together they form a unique fingerprint.

Cite this