Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract

T.T.J.M. Berendschot, W. Broekmans, I.A.A. Klopping-Ketelaars, A.F.M. Kardinaal, G. van Poppel, D. van Norren

Research output: Contribution to journalArticleAcademicpeer-review

56 Citations (Scopus)

Abstract

Objective To investigate whether nutritional factors and possible risk factors for cataract influence the lens optical density (LOD). Design Three hundred seventy-six subjects, aged 18 to 75 years, were recruited. In a cross-sectional design, serum was analyzed for lutein, zeaxanthin, vitamin C, -tocopherol, and cholesterol levels. Adipose tissue (n = 187) was analyzed for lutein level. The LOD and the macular pigment optical density (MPOD) were measured by spectral fundus reflectance. Results The mean ± SD LOD at 420 nm was 0.52 ± 0.17. It showed a significant association with age ( = .008, P
Original languageEnglish
Pages (from-to)1732-1737
JournalArchives of Ophthalmology
Volume120
Issue number12
Publication statusPublished - 2002

Keywords

  • beaver dam eye
  • macular pigment density
  • human crystalline lens
  • body-mass index
  • cigarette-smoking
  • optical-density
  • vitamin-c
  • antioxidant vitamins
  • nuclear opacities
  • serum carotenoids

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