Lectin receptor kinases: sentinels in defense against plant pathogens

Research output: Chapter in Book/Report/Conference proceedingAbstract

Abstract

Plant breeders continuously face the challenge to obtain new cultivars with adequate levels of resistance to a variety of pathogens. In recent years, we identified a novel type of immune receptors that could be employed as disease resistance components towards both Phytophthora and bacterial pathogens. This resistance is mediated by cell surface receptors belonging to the family of L-type lectin receptor kinases (LecRKs). LecRKs are wide-spread in plants, and justifies exploitation of LecRKs as novel sources of crop resistance. The LecRK multi-gene family in Arabidopsis consists of 45 members, and their individual role in defense was determined in a genome-wide phenotypic analysis of T-DNA insertion mutants in infection assays. We found that multiple LecRKs play a role in resistance to a variety of plant pathogens, and that overexpression of various LecRKs enhances disease resistance. In addition, we screened for LecRK-Interacting-Proteins (LIPs) usingmass spectrometry. LecRK interaction was confirmed for one of the candidates, LIP1, in co-immunoprecipation assays. Further functional analysis showed that Arabidopsis Lip1 mutants are compromised in Phytophthora resistance in a similar fashion as LecRK mutant lines. Understanding how LecRK-mediated resistance is functioning is crucial to design novel resistance in crops against Phytophthora and bacterial plant pathogens.
Original languageEnglish
Title of host publicationBook of Abstracts COST 2014 - 2nd Annual Conference of the SUSTAIN Action
Pages25
Publication statusPublished - 2014
EventCOST 2014 - 2nd Annual Conference of the SUSTAIN Action, Zakopane, Poland -
Duration: 15 Oct 201417 Oct 2014

Conference

ConferenceCOST 2014 - 2nd Annual Conference of the SUSTAIN Action, Zakopane, Poland
Period15/10/1417/10/14

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  • Cite this

    Wang, Y., Govers, F., & Bouwmeester, K. (2014). Lectin receptor kinases: sentinels in defense against plant pathogens. In Book of Abstracts COST 2014 - 2nd Annual Conference of the SUSTAIN Action (pp. 25)