Lectin receptor kinase; sentinels in defense against plant pathogens

Research output: Chapter in Book/Report/Conference proceedingAbstract

Abstract

Plant breeders continuously face the challenge to obtain new cultivars with adequate levels of resistance to a variety of pathogens. In recent years, we identified a novel type of immune receptors that could be employed as disease resistance components towards both Phytophthora and bacterial pathogens. This resistance is mediated by cell surface receptors belonging to the family of L-type lectin receptor kinases (LecRKs). LecRKs are wide-spread in plants, and justifies exploitation of LecRKs as novel sources of crop resistance. The LecRK multi-gene family in Arabidopsis consists of 45 members, and their individual role in defense was determined in a genome-wide phenotypic analysis of T-DNA insertion mutants in infection assays. We found that multiple LecRKs play a role in resistance to a variety of plant pathogens, and that overexpression of various LecRKs enhances disease resistance. In addition, we screened for LecRKlnteracting- Proteins (LIPs) using mass spectrometry. LecRK interaction was confirmed for one of the candidates, LIP1, in co-immunoprecipitation assays. Further functional analysis showed that Arabidopsis Lip1 mutants are compromised in Phytophthora resistance in a similar fashion as LecRK mutant lines. Understanding how LecRKmediated resistance is functioning is crucial to design novel resistance in crops against Phytophthora and bacterial plant pathogens.
Original languageEnglish
Title of host publicationBook of Abstracts Oomycete Molecular Genetics Network Meeting
Pages17
Publication statusPublished - 2015
EventOomycete Molecular Genetics Network Meeting 2015 - Pacific Grove, United States
Duration: 14 Mar 201517 Mar 2015

Conference

ConferenceOomycete Molecular Genetics Network Meeting 2015
CountryUnited States
CityPacific Grove
Period14/03/1517/03/15

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    Wang, Y., Govers, F., & Bouwmeester, K. (2015). Lectin receptor kinase; sentinels in defense against plant pathogens. In Book of Abstracts Oomycete Molecular Genetics Network Meeting (pp. 17)