LC-NMR coupling technology: recent advancements and applications in natural products analysis

V. Exarchou; M. Krucker; T.A. van Beek; J.J.M. Vervoort; I.P. Gerothanassis; K. Albert

doi:10.1002/mrc.1632

LC-NMR coupling technology: recent advancements and applications in natural products analysis

V. Exarchou, M. Krucker, T.A. van Beek, J.J.M. Vervoort, I.P. Gerothanassis, K. Albert

Research output: Contribution to journal › Article › Academic › peer-review

94 Citations (Scopus)

Abstract

An overview of recent advances in nuclear magnetic resonance (NMR) coupled with separation technologies and their application in natural product analysis is given and discussed. The different modes of LC-NMR operation are described, as well as how technical improvements assist in establishing LC-NMR as an important tool in the analysis of plant-derived compounds. On-flow, stopped-flow and loop-storage procedures are mentioned, together with the new LC-SPE-NMR configuration. The implementation of mass spectrometry in LC-NMR is also useful on account of the molecular weight and fragmentation information that it provides, especially when new plant species are studied. Cryogenic technology and capillary LC-NMR are the other important recent developments. Since the plant kingdom is endless in producing potential drug candidates, development and optimization of LC-NMR techniques convert the study of natural products to a less-time-consuming task, speeding up identification

Original language	English
Pages (from-to)	681-687
Journal	Magnetic Resonance in Chemistry
Volume	43
Issue number	9
DOIs	https://doi.org/10.1002/mrc.1632
Publication status	Published - 2005

Keywords

nuclear-magnetic-resonance
performance liquid-chromatography
solid-phase extraction
high-resolution nmr
tandem mass-spectrometry
crude plant-extracts
dad-spe-nmr
hplc-nmr
naphthylisoquinoline alkaloids
solvent-suppression

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10.1002/mrc.1632

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title = "LC-NMR coupling technology: recent advancements and applications in natural products analysis",

abstract = "An overview of recent advances in nuclear magnetic resonance (NMR) coupled with separation technologies and their application in natural product analysis is given and discussed. The different modes of LC-NMR operation are described, as well as how technical improvements assist in establishing LC-NMR as an important tool in the analysis of plant-derived compounds. On-flow, stopped-flow and loop-storage procedures are mentioned, together with the new LC-SPE-NMR configuration. The implementation of mass spectrometry in LC-NMR is also useful on account of the molecular weight and fragmentation information that it provides, especially when new plant species are studied. Cryogenic technology and capillary LC-NMR are the other important recent developments. Since the plant kingdom is endless in producing potential drug candidates, development and optimization of LC-NMR techniques convert the study of natural products to a less-time-consuming task, speeding up identification",

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author = "V. Exarchou and M. Krucker and {van Beek}, T.A. and J.J.M. Vervoort and I.P. Gerothanassis and K. Albert",

year = "2005",

doi = "10.1002/mrc.1632",

language = "English",

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journal = "Magnetic Resonance in Chemistry",

issn = "0749-1581",

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AU - Exarchou, V.

AU - Krucker, M.

AU - van Beek, T.A.

AU - Vervoort, J.J.M.

AU - Gerothanassis, I.P.

AU - Albert, K.

PY - 2005

Y1 - 2005

N2 - An overview of recent advances in nuclear magnetic resonance (NMR) coupled with separation technologies and their application in natural product analysis is given and discussed. The different modes of LC-NMR operation are described, as well as how technical improvements assist in establishing LC-NMR as an important tool in the analysis of plant-derived compounds. On-flow, stopped-flow and loop-storage procedures are mentioned, together with the new LC-SPE-NMR configuration. The implementation of mass spectrometry in LC-NMR is also useful on account of the molecular weight and fragmentation information that it provides, especially when new plant species are studied. Cryogenic technology and capillary LC-NMR are the other important recent developments. Since the plant kingdom is endless in producing potential drug candidates, development and optimization of LC-NMR techniques convert the study of natural products to a less-time-consuming task, speeding up identification

AB - An overview of recent advances in nuclear magnetic resonance (NMR) coupled with separation technologies and their application in natural product analysis is given and discussed. The different modes of LC-NMR operation are described, as well as how technical improvements assist in establishing LC-NMR as an important tool in the analysis of plant-derived compounds. On-flow, stopped-flow and loop-storage procedures are mentioned, together with the new LC-SPE-NMR configuration. The implementation of mass spectrometry in LC-NMR is also useful on account of the molecular weight and fragmentation information that it provides, especially when new plant species are studied. Cryogenic technology and capillary LC-NMR are the other important recent developments. Since the plant kingdom is endless in producing potential drug candidates, development and optimization of LC-NMR techniques convert the study of natural products to a less-time-consuming task, speeding up identification

KW - nuclear-magnetic-resonance

KW - performance liquid-chromatography

KW - solid-phase extraction

KW - high-resolution nmr

KW - tandem mass-spectrometry

KW - crude plant-extracts

KW - dad-spe-nmr

KW - hplc-nmr

KW - naphthylisoquinoline alkaloids

KW - solvent-suppression

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DO - 10.1002/mrc.1632

M3 - Article

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EP - 687

JO - Magnetic Resonance in Chemistry

JF - Magnetic Resonance in Chemistry

IS - 9

ER -

LC-NMR coupling technology: recent advancements and applications in natural products analysis

Abstract

Keywords

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