Lateral flow immunoassays

Aart Van Amerongen, Jeroen Veen, Hugo A. Arends, Marjo Koets

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

10 Citations (Scopus)

Abstract

The lateral flow (immuno)assay is a relatively old diagnostic platform that was developed in the 1980s. Over the almost 30 years since, a very diverse panel of lateral flow immunoassays has been developed and marketed. At the moment the platform is being transformed into a modern diagnostic tool that can be integrated with nowadays technologies, such as optical and electrochemical transducers and wireless data transfer. In addition, more sensitive detection principles have become available. The way forward for this technology is the development of sensitive, multianalyte, and quantitative assays that can compete with some of the diagnostics now used in the laboratory. A lateral flow reader dedicated to microarray and/or quantitative assays is absolutely needed to process the data to the user-friendly results. Challenges and future directions of the lateral flow platform are the combination with nucleic acid amplification procedures and the further integration with paper diagnostics. As is evident from the scientific literature and the commercial market, the lateral flow diagnostic platform is being transformed into a competitive diagnostic by the combination with and the incorporation of advanced technologies.

Original languageEnglish
Title of host publicationHandbook of Immunoassay Technologies
Subtitle of host publicationApproaches, Performances, and Applications
EditorsS.K. Vashist, J.H.T. Luong
PublisherElsevier
Pages157-182
Number of pages26
ISBN (Electronic)9780128117620
ISBN (Print)9780128117941
DOIs
Publication statusPublished - 29 Jan 2018

Keywords

  • Diagnostic
  • Lateral flow
  • Microarray
  • Nucleic acids
  • On-site
  • Point-of-care
  • Real-time reader
  • User-friendly

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  • Cite this

    Van Amerongen, A., Veen, J., Arends, H. A., & Koets, M. (2018). Lateral flow immunoassays. In S. K. Vashist, & J. H. T. Luong (Eds.), Handbook of Immunoassay Technologies: Approaches, Performances, and Applications (pp. 157-182). Elsevier. https://doi.org/10.1016/B978-0-12-811762-0.00007-4