Lateral flow (immuno)assay: its strengths, weaknesses, opportunities and threats. A literature survey

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910 Citations (Scopus)

Abstract

Lateral flow (immuno)assays are currently used for qualitative, semiquantitative and to some extent quantitative monitoring in resource-poor or non-laboratory environments. Applications include tests on pathogens, drugs, hormones and metabolites in biomedical, phytosanitary, veterinary, feed/food and environmental settings. We describe principles of current formats, applications, limitations and perspectives for quantitative monitoring. We illustrate the potentials and limitations of analysis with lateral flow (immuno)assays using a literature survey and a SWOT analysis (acronym for 'strengths, weaknesses, opportunities, threats'). Articles referred to in this survey were searched for on MEDLINE, Scopus and in references of reviewed papers. Search terms included 'immunochromatography', 'sol particle immunoassay', 'lateral flow immunoassay' and 'dipstick assay'.
Original languageEnglish
Pages (from-to)569-582
JournalAnalytical and Bioanalytical Chemistry
Volume393
Issue number2
DOIs
Publication statusPublished - 2009

Keywords

  • converting phosphor technology
  • competitive immunochromatographic assay
  • immunoglobulin-m antibodies
  • linked-immunosorbent-assay
  • dipstick dye immunoassay
  • dry reagent immunoassay
  • computer image-analysis
  • fungal alpha-amylase
  • step strip test
  • rapid dete

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