Low-temperature bonding of glass substrates is of great interest in the field of microfluidic-based biosensing, and we study how laser welding could be used for this. This technology allows for the modification of glass channels with temperature-sensitive materials prior to bonding. We study the effects of the welding process by investigation of the thermal degradation of a biotin monolayer and whether it retains the ability to conjugate with fluorescently-labelled streptavidin.
- laser welding
- low temperature bonding
Carvalho, R. R., Reuvekamp, S., Zuilhof, H., Blom, M. T., & Vrouwe, E. X. (2018). Laser welding of pre-functionalized glass substrates: A fabrication and chemical stability study. Journal of Micromechanics and Microengineering, 28(1), . https://doi.org/10.1088/1361-6439/aa9962