Lactic acid bacteria for delivery of endogenous or engineered therapeutic molecules

Peter A. Bron, Michiel Kleerebezem*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Food-grade lactic acid bacteria (LAB) are considered suitable vehicles for the production and/or delivery of health promoting or therapeutic, bioactive molecules. The molecules considered for health-beneficial use include the endogenous effector molecules produced by probiotics (mostly lactobacilli), as well as heterologous bioactives that can be produced in LAB by genetic engineering (mostly using lactococci). Both strategies aim to deliver appropriate dosages of specific bioactive molecules to the site of action. This review uses specific examples of both strategies to illustrate the different avenues of research involved in these applications as well as their translation to human health-promoting applications. These examples pinpoint that despite the promising perspectives of these approaches, the evidence for their effective applications in human populations is lagging behind.

Original languageEnglish
Article number1821
JournalFrontiers in Microbiology
Volume9
Issue numberAUG
DOIs
Publication statusPublished - 3 Aug 2018

Fingerprint

Lactic Acid
Bacteria
Health
Lactococcus
Genetic Engineering
Probiotics
Lactobacillus
Therapeutics
Food
Research
Population

Keywords

  • Genetic engineering
  • Lactic acid bacteria
  • Lactobacillus
  • Lactococcus lactis
  • Probiotics
  • Therapeutic molecules

Cite this

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title = "Lactic acid bacteria for delivery of endogenous or engineered therapeutic molecules",
abstract = "Food-grade lactic acid bacteria (LAB) are considered suitable vehicles for the production and/or delivery of health promoting or therapeutic, bioactive molecules. The molecules considered for health-beneficial use include the endogenous effector molecules produced by probiotics (mostly lactobacilli), as well as heterologous bioactives that can be produced in LAB by genetic engineering (mostly using lactococci). Both strategies aim to deliver appropriate dosages of specific bioactive molecules to the site of action. This review uses specific examples of both strategies to illustrate the different avenues of research involved in these applications as well as their translation to human health-promoting applications. These examples pinpoint that despite the promising perspectives of these approaches, the evidence for their effective applications in human populations is lagging behind.",
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Lactic acid bacteria for delivery of endogenous or engineered therapeutic molecules. / Bron, Peter A.; Kleerebezem, Michiel.

In: Frontiers in Microbiology, Vol. 9, No. AUG, 1821, 03.08.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Lactic acid bacteria for delivery of endogenous or engineered therapeutic molecules

AU - Bron, Peter A.

AU - Kleerebezem, Michiel

PY - 2018/8/3

Y1 - 2018/8/3

N2 - Food-grade lactic acid bacteria (LAB) are considered suitable vehicles for the production and/or delivery of health promoting or therapeutic, bioactive molecules. The molecules considered for health-beneficial use include the endogenous effector molecules produced by probiotics (mostly lactobacilli), as well as heterologous bioactives that can be produced in LAB by genetic engineering (mostly using lactococci). Both strategies aim to deliver appropriate dosages of specific bioactive molecules to the site of action. This review uses specific examples of both strategies to illustrate the different avenues of research involved in these applications as well as their translation to human health-promoting applications. These examples pinpoint that despite the promising perspectives of these approaches, the evidence for their effective applications in human populations is lagging behind.

AB - Food-grade lactic acid bacteria (LAB) are considered suitable vehicles for the production and/or delivery of health promoting or therapeutic, bioactive molecules. The molecules considered for health-beneficial use include the endogenous effector molecules produced by probiotics (mostly lactobacilli), as well as heterologous bioactives that can be produced in LAB by genetic engineering (mostly using lactococci). Both strategies aim to deliver appropriate dosages of specific bioactive molecules to the site of action. This review uses specific examples of both strategies to illustrate the different avenues of research involved in these applications as well as their translation to human health-promoting applications. These examples pinpoint that despite the promising perspectives of these approaches, the evidence for their effective applications in human populations is lagging behind.

KW - Genetic engineering

KW - Lactic acid bacteria

KW - Lactobacillus

KW - Lactococcus lactis

KW - Probiotics

KW - Therapeutic molecules

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JO - Frontiers in Microbiology

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