Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection

H.W. Barkema, K. Orsel, S. Nielsen, Ad Koets, V.P.M.G. Rutten, J.P. Bannantine, G.P. Keefe, D.F. Kelton, S.J. Wells, R.J. Whittington, C.G. Mackintosh, E.J. Manning, M.F. Weber, C. Heuer, T.L. Forde, C. Ritter, S. Roche, C.S. Corbett, R. Wolf, P.J. Griebel & 2 others J.P. Kastelic, J. De Buck

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18 Citations (Scopus)

Abstract

In the last decades, many regional and country-wide control programmes for Johne's disease (JD) were developed due to associated economic losses, or because of a possible association with Crohn's disease. These control programmes were often not successful, partly because management protocols were not followed, including the introduction of infected replacement cattle, because tests to identify infected animals were unreliable, and uptake by farmers was not high enough because of a perceived low return on investment. In the absence of a cure or effective commercial vaccines, control of JD is currently primarily based on herd management strategies to avoid infection of cattle and restrict within-farm and farm-to-farm transmission. Although JD control programmes have been implemented in most developed countries, lessons learned from JD prevention and control programmes are underreported. Also, JD control programmes are typically evaluated in a limited number of herds and the duration of the study is less than 5 year, making it difficult to adequately assess the efficacy of control programmes. In this manuscript, we identify the most important gaps in knowledge hampering JD prevention and control programmes, including vaccination and diagnostics. Secondly, we discuss directions that research should take to address those knowledge gaps
Original languageEnglish
Pages (from-to)125-148
JournalTransboundary and Emerging Diseases
Volume65
Issue numberS1
Early online date22 Sep 2017
DOIs
Publication statusPublished - May 2018

Fingerprint

Mycobacterium avium subsp. paratuberculosis
Paratuberculosis
Mycobacterium avium
paratuberculosis
Infection
infection
disease control programs
disease prevention
farms
disease control
herds
Crohn disease
cattle
Developed Countries
developed countries
Crohn Disease
Vaccination
Vaccines
vaccination
Economics

Cite this

Barkema, H.W. ; Orsel, K. ; Nielsen, S. ; Koets, Ad ; Rutten, V.P.M.G. ; Bannantine, J.P. ; Keefe, G.P. ; Kelton, D.F. ; Wells, S.J. ; Whittington, R.J. ; Mackintosh, C.G. ; Manning, E.J. ; Weber, M.F. ; Heuer, C. ; Forde, T.L. ; Ritter, C. ; Roche, S. ; Corbett, C.S. ; Wolf, R. ; Griebel, P.J. ; Kastelic, J.P. ; De Buck, J. . / Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection. In: Transboundary and Emerging Diseases. 2018 ; Vol. 65, No. S1. pp. 125-148.
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title = "Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection",
abstract = "In the last decades, many regional and country-wide control programmes for Johne's disease (JD) were developed due to associated economic losses, or because of a possible association with Crohn's disease. These control programmes were often not successful, partly because management protocols were not followed, including the introduction of infected replacement cattle, because tests to identify infected animals were unreliable, and uptake by farmers was not high enough because of a perceived low return on investment. In the absence of a cure or effective commercial vaccines, control of JD is currently primarily based on herd management strategies to avoid infection of cattle and restrict within-farm and farm-to-farm transmission. Although JD control programmes have been implemented in most developed countries, lessons learned from JD prevention and control programmes are underreported. Also, JD control programmes are typically evaluated in a limited number of herds and the duration of the study is less than 5 year, making it difficult to adequately assess the efficacy of control programmes. In this manuscript, we identify the most important gaps in knowledge hampering JD prevention and control programmes, including vaccination and diagnostics. Secondly, we discuss directions that research should take to address those knowledge gaps",
author = "H.W. Barkema and K. Orsel and S. Nielsen and Ad Koets and V.P.M.G. Rutten and J.P. Bannantine and G.P. Keefe and D.F. Kelton and S.J. Wells and R.J. Whittington and C.G. Mackintosh and E.J. Manning and M.F. Weber and C. Heuer and T.L. Forde and C. Ritter and S. Roche and C.S. Corbett and R. Wolf and P.J. Griebel and J.P. Kastelic and {De Buck}, J.",
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doi = "10.1111/tbed.12723",
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Barkema, HW, Orsel, K, Nielsen, S, Koets, A, Rutten, VPMG, Bannantine, JP, Keefe, GP, Kelton, DF, Wells, SJ, Whittington, RJ, Mackintosh, CG, Manning, EJ, Weber, MF, Heuer, C, Forde, TL, Ritter, C, Roche, S, Corbett, CS, Wolf, R, Griebel, PJ, Kastelic, JP & De Buck, J 2018, 'Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection' Transboundary and Emerging Diseases, vol. 65, no. S1, pp. 125-148. https://doi.org/10.1111/tbed.12723

Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection. / Barkema, H.W.; Orsel, K.; Nielsen, S.; Koets, Ad; Rutten, V.P.M.G.; Bannantine, J.P.; Keefe, G.P.; Kelton, D.F. ; Wells, S.J.; Whittington, R.J.; Mackintosh, C.G.; Manning, E.J.; Weber, M.F.; Heuer, C.; Forde, T.L.; Ritter, C.; Roche, S.; Corbett, C.S.; Wolf, R.; Griebel, P.J.; Kastelic, J.P.; De Buck, J. .

In: Transboundary and Emerging Diseases, Vol. 65, No. S1, 05.2018, p. 125-148.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection

AU - Barkema, H.W.

AU - Orsel, K.

AU - Nielsen, S.

AU - Koets, Ad

AU - Rutten, V.P.M.G.

AU - Bannantine, J.P.

AU - Keefe, G.P.

AU - Kelton, D.F.

AU - Wells, S.J.

AU - Whittington, R.J.

AU - Mackintosh, C.G.

AU - Manning, E.J.

AU - Weber, M.F.

AU - Heuer, C.

AU - Forde, T.L.

AU - Ritter, C.

AU - Roche, S.

AU - Corbett, C.S.

AU - Wolf, R.

AU - Griebel, P.J.

AU - Kastelic, J.P.

AU - De Buck, J.

PY - 2018/5

Y1 - 2018/5

N2 - In the last decades, many regional and country-wide control programmes for Johne's disease (JD) were developed due to associated economic losses, or because of a possible association with Crohn's disease. These control programmes were often not successful, partly because management protocols were not followed, including the introduction of infected replacement cattle, because tests to identify infected animals were unreliable, and uptake by farmers was not high enough because of a perceived low return on investment. In the absence of a cure or effective commercial vaccines, control of JD is currently primarily based on herd management strategies to avoid infection of cattle and restrict within-farm and farm-to-farm transmission. Although JD control programmes have been implemented in most developed countries, lessons learned from JD prevention and control programmes are underreported. Also, JD control programmes are typically evaluated in a limited number of herds and the duration of the study is less than 5 year, making it difficult to adequately assess the efficacy of control programmes. In this manuscript, we identify the most important gaps in knowledge hampering JD prevention and control programmes, including vaccination and diagnostics. Secondly, we discuss directions that research should take to address those knowledge gaps

AB - In the last decades, many regional and country-wide control programmes for Johne's disease (JD) were developed due to associated economic losses, or because of a possible association with Crohn's disease. These control programmes were often not successful, partly because management protocols were not followed, including the introduction of infected replacement cattle, because tests to identify infected animals were unreliable, and uptake by farmers was not high enough because of a perceived low return on investment. In the absence of a cure or effective commercial vaccines, control of JD is currently primarily based on herd management strategies to avoid infection of cattle and restrict within-farm and farm-to-farm transmission. Although JD control programmes have been implemented in most developed countries, lessons learned from JD prevention and control programmes are underreported. Also, JD control programmes are typically evaluated in a limited number of herds and the duration of the study is less than 5 year, making it difficult to adequately assess the efficacy of control programmes. In this manuscript, we identify the most important gaps in knowledge hampering JD prevention and control programmes, including vaccination and diagnostics. Secondly, we discuss directions that research should take to address those knowledge gaps

U2 - 10.1111/tbed.12723

DO - 10.1111/tbed.12723

M3 - Article

VL - 65

SP - 125

EP - 148

JO - Transboundary and Emerging Diseases

JF - Transboundary and Emerging Diseases

SN - 1865-1674

IS - S1

ER -