Isohexide Derivatives from Renewable Resources as Chiral Building Blocks

J. Wu, P. Eduard, S. Thiyagarajan, J. van Haveren, D.S. van Es, C.E. Koning, M. Lutz, C. Fonesca Guerra

Research output: Contribution to journalArticleAcademicpeer-review

60 Citations (Scopus)


A new family of C2/C5 carbon-extended isohexide derivatives is synthesized in a stereo-controlled manner with high purity and good yield. These chiral and rigid biobased building blocks can be widely applied: in pharmaceuticals, cholesteric liquid crystals, and as building blocks for high-performance polymers. The isoidide-based diacid is a potential renewable alternative to terephthalic acid.
Original languageEnglish
Pages (from-to)599-603
Issue number5
Publication statusPublished - 2011


  • asymmetric transfer hydrogenation
  • molecular structure
  • terephthalic acid
  • crystal-structure
  • isosorbide
  • chemistry
  • polymers
  • ligands
  • polyurethanes
  • isomannide

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