Systems biology requires the availability, co-ordination and simultaneous interaction of a large number of diverse facilities and activities. These cover an entire spectrum, from mathematical modelling, through biological, biomedical and clinical experiments, to dedicated technology development. The systems biology community needs close cooperation with data-generation groups and bioinformaticians to define a strategy for producing life-science data of sufficiently high quality for model generation. For each medical, biological or biotechnological problem addressed, the optimal combination of facilities and activities is likely to be different. The complexity of biological systems, and the diversity and dynamics of their processes, means that a full analysis is far too complex to be handled by a single entity, industry or country – a variety of specialist expertise and facilities are typically necessary to achieve results suitable for modelling. Systems-level approaches for tackling the complexity of life-science data provide a profound conceptual advance compared to reductionist biological research methods of the past. Rather than focusing on individual laboratories, specialising in a limited number of research technologies, the Infrastructure for Systems Biology in Europe (ISBE) will facilitate the synergistic application of a wide range of research techniques and technologies to problems of major medical and biotechnological importance.
|Publication status||Published - 2013|
Hollmann, S., Martins dos Santos, V. A. P., & Regierer, B. (2013). ISBE – set out for a Systems Biology Infrastructure for Europe. EMBnet.journal, 19(1), 3-4. http://journal.embnet.org/index.php/embnetjournal/article/view/696/975