Gliadin was broken down by pepsin and trypsin to a peptide mixture. In continuance of an investigation of the coeliac disease by other research workers, fractions were isolated from this peptide mixture and tested for toxicity in patients with idiopathic steatorrhoea.
An acid peptide fraction obtained by adsorption on acid aluminiurn oxide was toxic. Disulphide bonds between peptide chains proved not to be responsible for this toxicity. Probably it was a mixture of a small group of related peptides containing about 35 amino acids.
|Qualification||Doctor of Philosophy|
|Award date||28 Jun 1963|
|Place of Publication||Rotterdam|
|Publication status||Published - 1963|
- triticum aestivum
- nutritional disorders