Projects per year
Food-derived peptides are known to possess inhibitory activity against the dipeptidyl-peptidase IV (DPP-IV) enzyme, a target in the management of type 2 diabetes. While proteins from commonly consumed food commodities have been investigated as precursors of DPP-IV-inhibiting peptides, studies on novel protein sources, such as those from insects, are sparse. This research aimed to determine if DPP-IV inhibitors can be generated upon in vitro digestion or enzymatic hydrolysis of lesser mealworm protein isolate and concentrate. Treatment of the proteins with digestive enzymes and proteases generated hydrolysates with varying potency, thermolysin being the most effective at releasing active peptides (IC50= 0.63 and 0.60 mg mL−1 for the isolate and concentrate). Ultrafiltration of the thermolysin-treated hydrolysates did not significantly improve the potency. This study shows that DPP-IV inhibitors can be generated from lesser mealworm protein and provides insight on the potential of insects to serve as functional food ingredients.
|Number of pages||9|
|Journal||International Journal of Food Science and Technology|
|Early online date||16 Oct 2018|
|Publication status||Published - Mar 2019|
- Dipeptidyl-peptidase IV inhibitors
- in vitro digestion
- lesser mealworm (A. diaperinus) protein
- type 2 diabetes
FingerprintDive into the research topics of 'Investigation into the potential of commercially available lesser mealworm (A. diaperinus) protein to serve as sources of peptides with DPP-IV inhibitory activity'. Together they form a unique fingerprint.
- 1 Finished
IVSysImmunoProt: Development of an in vitro cellular model to predict the immunological impact of dietary proteins
1/09/16 → 31/08/18
Project: EU research project