Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

Rahajeng N. Tunjungputri*, Marien I. de Jonge, Astrid de Greeff, Saskia van Selm, Herma Buys-Bergen, Jose F. Harders-Westerveen, Norbert Stockhofe-Zurwieden, Rolf T. Urbanus, Phillip G. De Groot, Hilde E. Smith, Andre J. van der Ven, Quirijn de Mast

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.

Original languageEnglish
Pages (from-to)123-126
JournalThrombosis Research
Volume144
DOIs
Publication statusPublished - 2016

Fingerprint

Pneumococcal Infections
Platelet Activation
Blood Vessels
Swine

Keywords

  • Infection
  • Myocardial infarction
  • Platelet activation
  • Platelets
  • Pneumonia
  • Streptococcus pneumoniae

Cite this

Tunjungputri, Rahajeng N. ; de Jonge, Marien I. ; de Greeff, Astrid ; van Selm, Saskia ; Buys-Bergen, Herma ; Harders-Westerveen, Jose F. ; Stockhofe-Zurwieden, Norbert ; Urbanus, Rolf T. ; De Groot, Phillip G. ; Smith, Hilde E. ; van der Ven, Andre J. ; de Mast, Quirijn. / Invasive pneumococcal disease leads to activation and hyperreactivity of platelets. In: Thrombosis Research. 2016 ; Vol. 144. pp. 123-126.
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abstract = "Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.",
keywords = "Infection, Myocardial infarction, Platelet activation, Platelets, Pneumonia, Streptococcus pneumoniae",
author = "Tunjungputri, {Rahajeng N.} and {de Jonge}, {Marien I.} and {de Greeff}, Astrid and {van Selm}, Saskia and Herma Buys-Bergen and Harders-Westerveen, {Jose F.} and Norbert Stockhofe-Zurwieden and Urbanus, {Rolf T.} and {De Groot}, {Phillip G.} and Smith, {Hilde E.} and {van der Ven}, {Andre J.} and {de Mast}, Quirijn",
year = "2016",
doi = "10.1016/j.thromres.2016.06.016",
language = "English",
volume = "144",
pages = "123--126",
journal = "Thrombosis Research",
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Tunjungputri, RN, de Jonge, MI, de Greeff, A, van Selm, S, Buys-Bergen, H, Harders-Westerveen, JF, Stockhofe-Zurwieden, N, Urbanus, RT, De Groot, PG, Smith, HE, van der Ven, AJ & de Mast, Q 2016, 'Invasive pneumococcal disease leads to activation and hyperreactivity of platelets', Thrombosis Research, vol. 144, pp. 123-126. https://doi.org/10.1016/j.thromres.2016.06.016

Invasive pneumococcal disease leads to activation and hyperreactivity of platelets. / Tunjungputri, Rahajeng N.; de Jonge, Marien I.; de Greeff, Astrid; van Selm, Saskia; Buys-Bergen, Herma; Harders-Westerveen, Jose F.; Stockhofe-Zurwieden, Norbert; Urbanus, Rolf T.; De Groot, Phillip G.; Smith, Hilde E.; van der Ven, Andre J.; de Mast, Quirijn.

In: Thrombosis Research, Vol. 144, 2016, p. 123-126.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

AU - Tunjungputri, Rahajeng N.

AU - de Jonge, Marien I.

AU - de Greeff, Astrid

AU - van Selm, Saskia

AU - Buys-Bergen, Herma

AU - Harders-Westerveen, Jose F.

AU - Stockhofe-Zurwieden, Norbert

AU - Urbanus, Rolf T.

AU - De Groot, Phillip G.

AU - Smith, Hilde E.

AU - van der Ven, Andre J.

AU - de Mast, Quirijn

PY - 2016

Y1 - 2016

N2 - Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.

AB - Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.

KW - Infection

KW - Myocardial infarction

KW - Platelet activation

KW - Platelets

KW - Pneumonia

KW - Streptococcus pneumoniae

U2 - 10.1016/j.thromres.2016.06.016

DO - 10.1016/j.thromres.2016.06.016

M3 - Article

VL - 144

SP - 123

EP - 126

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

ER -