Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

Rahajeng N. Tunjungputri; Marien I. de Jonge; Astrid de Greeff; Saskia van Selm; Herma Buys-Bergen; Jose F. Harders-Westerveen; Norbert Stockhofe-Zurwieden; Rolf T. Urbanus; Phillip G. De Groot; Hilde E. Smith; Andre J. van der Ven; Quirijn de Mast

doi:10.1016/j.thromres.2016.06.016

Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

Rahajeng N. Tunjungputri^*, Marien I. de Jonge, Astrid de Greeff, Saskia van Selm, Herma Buys-Bergen, Jose F. Harders-Westerveen, Norbert Stockhofe-Zurwieden, Rolf T. Urbanus, Phillip G. De Groot, Hilde E. Smith, Andre J. van der Ven, Quirijn de Mast

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.

Original language	English
Pages (from-to)	123-126
Journal	Thrombosis Research
Volume	144
DOIs	https://doi.org/10.1016/j.thromres.2016.06.016
Publication status	Published - 2016

Keywords

Infection
Myocardial infarction
Platelet activation
Platelets
Pneumonia
Streptococcus pneumoniae

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10.1016/j.thromres.2016.06.016

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Tunjungputri, R. N., de Jonge, M. I., de Greeff, A., van Selm, S., Buys-Bergen, H., Harders-Westerveen, J. F., Stockhofe-Zurwieden, N., Urbanus, R. T., De Groot, P. G., Smith, H. E., van der Ven, A. J., & de Mast, Q. (2016). Invasive pneumococcal disease leads to activation and hyperreactivity of platelets. Thrombosis Research, 144, 123-126. https://doi.org/10.1016/j.thromres.2016.06.016

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title = "Invasive pneumococcal disease leads to activation and hyperreactivity of platelets",

abstract = "Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.",

keywords = "Infection, Myocardial infarction, Platelet activation, Platelets, Pneumonia, Streptococcus pneumoniae",

author = "Tunjungputri, {Rahajeng N.} and {de Jonge}, {Marien I.} and {de Greeff}, Astrid and {van Selm}, Saskia and Herma Buys-Bergen and Harders-Westerveen, {Jose F.} and Norbert Stockhofe-Zurwieden and Urbanus, {Rolf T.} and {De Groot}, {Phillip G.} and Smith, {Hilde E.} and {van der Ven}, {Andre J.} and {de Mast}, Quirijn",

year = "2016",

doi = "10.1016/j.thromres.2016.06.016",

language = "English",

volume = "144",

pages = "123--126",

journal = "Thrombosis Research",

issn = "0049-3848",

publisher = "Elsevier",

}

Tunjungputri, RN, de Jonge, MI, de Greeff, A, van Selm, S, Buys-Bergen, H, Harders-Westerveen, JF , Stockhofe-Zurwieden, N, Urbanus, RT, De Groot, PG, Smith, HE, van der Ven, AJ & de Mast, Q 2016, 'Invasive pneumococcal disease leads to activation and hyperreactivity of platelets', Thrombosis Research, vol. 144, pp. 123-126. https://doi.org/10.1016/j.thromres.2016.06.016

TY - JOUR

T1 - Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

AU - Tunjungputri, Rahajeng N.

AU - de Jonge, Marien I.

AU - de Greeff, Astrid

AU - van Selm, Saskia

AU - Buys-Bergen, Herma

AU - Harders-Westerveen, Jose F.

AU - Stockhofe-Zurwieden, Norbert

AU - Urbanus, Rolf T.

AU - De Groot, Phillip G.

AU - Smith, Hilde E.

AU - van der Ven, Andre J.

AU - de Mast, Quirijn

PY - 2016

Y1 - 2016

N2 - Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.

AB - Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.

KW - Infection

KW - Myocardial infarction

KW - Platelet activation

KW - Platelets

KW - Pneumonia

KW - Streptococcus pneumoniae

U2 - 10.1016/j.thromres.2016.06.016

DO - 10.1016/j.thromres.2016.06.016

M3 - Article

AN - SCOPUS:84975217789

SN - 0049-3848

VL - 144

SP - 123

EP - 126

JO - Thrombosis Research

JF - Thrombosis Research

ER -

Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

Abstract

Keywords

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