Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

Rahajeng N. Tunjungputri*, Marien I. de Jonge, Astrid de Greeff, Saskia van Selm, Herma Buys-Bergen, Jose F. Harders-Westerveen, Norbert Stockhofe-Zurwieden, Rolf T. Urbanus, Phillip G. De Groot, Hilde E. Smith, Andre J. van der Ven, Quirijn de Mast

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.

Original languageEnglish
Pages (from-to)123-126
JournalThrombosis Research
Volume144
DOIs
Publication statusPublished - 2016

Keywords

  • Infection
  • Myocardial infarction
  • Platelet activation
  • Platelets
  • Pneumonia
  • Streptococcus pneumoniae

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    Tunjungputri, R. N., de Jonge, M. I., de Greeff, A., van Selm, S., Buys-Bergen, H., Harders-Westerveen, J. F., Stockhofe-Zurwieden, N., Urbanus, R. T., De Groot, P. G., Smith, H. E., van der Ven, A. J., & de Mast, Q. (2016). Invasive pneumococcal disease leads to activation and hyperreactivity of platelets. Thrombosis Research, 144, 123-126. https://doi.org/10.1016/j.thromres.2016.06.016