Intradermal vaccination of pigs against FMD with 1/10 dose results in comparable vaccine efficacy as intramuscular vaccination with a full dose

P.L. Eble, K. Weerdmeester, F. van Hemert-Kluitenberg, A. Dekker

    Research output: Contribution to journalArticleAcademicpeer-review

    16 Citations (Scopus)

    Abstract

    The aim of this study was to investigate whether intradermal (ID) vaccination against foot-and-mouth disease (FMD) is suitable as an alternative for the usually used intramuscular (IM) route. We compared vaccine efficacy in groups of pigs in which vaccine administration differed with respect to antigen payload of the vaccine, administrated volume and administration route. When compared with pigs that were IM vaccinated with a full dose vaccine with a standard antigen payload, pigs vaccinated ID with 1/10 dose of the same vaccine were equally protected against clinical disease and subclinical virus shedding. The ID vaccinated pigs were protected against virus shedding at a significant lower VN-titre as compared to IM vaccinated pigs, suggesting that immune responses other than neutralising antibodies also contributed to protection. We conclude that the ID route might be a good alternative for IM application, as ID application might induce a very efficient immunological response against FMD and, moreover, because the dose required by the ID route is lower compared to the IM route, ID application may reduce the production costs per dose of FMD vaccine markedly
    Original languageEnglish
    Pages (from-to)1272-1278
    JournalVaccine
    Volume27
    Issue number8
    DOIs
    Publication statusPublished - 2009

    Keywords

    • mouth-disease vaccines
    • hepatitis-b-vaccine
    • aujeszkys-disease
    • immune-responses
    • antibody-responses
    • virus
    • protection
    • influenza
    • infection
    • antigen

    Fingerprint Dive into the research topics of 'Intradermal vaccination of pigs against FMD with 1/10 dose results in comparable vaccine efficacy as intramuscular vaccination with a full dose'. Together they form a unique fingerprint.

  • Cite this