TY - JOUR
T1 - Intra- and interindividual variability in fasted gastric content volume
AU - Roelofs, Julia J.M.
AU - Camps, Guido
AU - Leenders, Louise M.
AU - Marciani, Luca
AU - Spiller, Robin C.
AU - Van Eijnatten, Elise J.M.
AU - Alyami, Jaber
AU - Deng, Ruoxuan
AU - Freitas, Daniela
AU - Grimm, Michael
AU - Karhunen, Leila J.
AU - Krishnasamy, Shanthi
AU - Le Feunteun, Steven
AU - Lobo, Dileep N.
AU - Mackie, Alan R.
AU - Mayar, Morwarid
AU - Weitschies, Werner
AU - Smeets, Paul A.M.
PY - 2024
Y1 - 2024
N2 - Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra- and interindividual variation in fasted gastric content volume (FGCV) and to determine the association with age, sex, and body size characteristics. Methods: Data from 24 MRI studies measuring FGCV in healthy, mostly young individuals after an overnight fast were pooled. The analysis included 366 participants who had up to 6 repeated measurements, with a total of 870 measurements. Linear mixed model analysis was performed to calculate intra- and interindividual variability and to assess the effects of age, sex, weight, height, weight*height as a proxy for body size, and body mass index (BMI). Results: FGCV ranged from 0 to 156 mL, with a mean (± SD) value of 33 ± 25 mL. The overall coefficient of variation within the study population was 75.6%, interindividual SD was 15 mL, and the intraindividual SD was 19 mL. Age, weight, height, weight*height, and BMI had no effect on FGCV. Women had lower volumes compared to men (MD: −6 mL), when corrected for the aforementioned factors. Conclusion: FGCV is highly variable, with higher intraindividual compared to interindividual variability, indicating that FGCV is subject to day-to-day and within-day variation and is not a stable personal characteristic. This highlights the importance of considering FGCV when studying digestion and drug dissolution. Exact implications remain to be studied.
AB - Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra- and interindividual variation in fasted gastric content volume (FGCV) and to determine the association with age, sex, and body size characteristics. Methods: Data from 24 MRI studies measuring FGCV in healthy, mostly young individuals after an overnight fast were pooled. The analysis included 366 participants who had up to 6 repeated measurements, with a total of 870 measurements. Linear mixed model analysis was performed to calculate intra- and interindividual variability and to assess the effects of age, sex, weight, height, weight*height as a proxy for body size, and body mass index (BMI). Results: FGCV ranged from 0 to 156 mL, with a mean (± SD) value of 33 ± 25 mL. The overall coefficient of variation within the study population was 75.6%, interindividual SD was 15 mL, and the intraindividual SD was 19 mL. Age, weight, height, weight*height, and BMI had no effect on FGCV. Women had lower volumes compared to men (MD: −6 mL), when corrected for the aforementioned factors. Conclusion: FGCV is highly variable, with higher intraindividual compared to interindividual variability, indicating that FGCV is subject to day-to-day and within-day variation and is not a stable personal characteristic. This highlights the importance of considering FGCV when studying digestion and drug dissolution. Exact implications remain to be studied.
KW - biological variation
KW - digestion
KW - gastric juice
KW - gastric volume
KW - MRI
U2 - 10.1111/nmo.14904
DO - 10.1111/nmo.14904
M3 - Article
AN - SCOPUS:85202029639
SN - 1350-1925
VL - 36
JO - Neurogastroenterology and Motility
JF - Neurogastroenterology and Motility
IS - 11
M1 - e14904
ER -