Intestinal integrity and Akkermansia muciniphila: a mucin-degrading member of the intestinal microbiota present in infants, adults and elderly

M.C. Collado, M.M.N. Derrien, E. Isolauri, W.M. de Vos, S. Salminen

Research output: Contribution to journalArticleAcademicpeer-review

253 Citations (Scopus)

Abstract

Fluorescence in situ hybridization and real-time PCR analysis targeting the 16S rRNA gene of Akkermansia muciniphila were performed to determine its presence in the human intestinal tract. These techniques revealed that an A. muciniphila-like bacterium is a common member of the human intestinal tract and that its colonization starts in early life and develops within a year to a level close to that observed in adults (10(8) cells/g) but decreases (P <0.05) in the elderly.
Original languageEnglish
Pages (from-to)7767-7770
JournalApplied and Environmental Microbiology
Volume73
Issue number23
DOIs
Publication statusPublished - 2007

Keywords

  • 16s ribosomal-rna
  • human fecal samples
  • flow-cytometry
  • diversity
  • communities
  • bacteria
  • gut
  • bifidobacteria
  • reveals
  • probes

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