Intervention strategies for cesarean section- induced alterations in the microbiota-gut-brain axis

Angela Moya-Pérez, Pauline Luczynski, Ingrid B. Renes, Shugui Wang, Yuliya Borre, C.A. Ryan, Jan Knol, Catherine Stanton, Timothy G. Dinan, John F. Cryan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

73 Citations (Scopus)


Microbial colonization of the gastrointestinal tract is an essential process that modulates host physiology and immunity. Recently, researchers have begun to understand how and when these microorganisms colonize the gut and the earlylife factors that impact their natural ecological establishment. The vertical transmission of maternal microbes to the offspring is a critical factor for host immune and metabolic development. Increasing evidence also points to a role in the wiring of the gut-brain axis. This process may be altered by various factors such as mode of delivery, gestational age at birth, the use of antibiotics in early life, infant feeding, and hygiene practices. In fact, these early exposures that impact the intestinal microbiota have been associated with the development of diseases such as obesity, type 1 diabetes, asthma, allergies, and even neurodevelopmental disorders. The present review summarizes the impact of cesarean birth on the gut microbiome and the health status of the developing infant and discusses possible preventative and restorative strategies to compensate for early-life microbial perturbations.

Original languageEnglish
Pages (from-to)225-240
JournalNutrition Reviews
Issue number4
Publication statusPublished - 2017


  • Cesarean section
  • Immunity
  • Metabolism
  • Microbiota
  • Prebiotics
  • Probiotics


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