Interleukin-10 and soluble tumor necrosis factor receptors in cerebrospinal fluid of children with bacterial meningitis

R.F. Kornelisse, H.F.J. Savelkoul, P.H.G. Mulder, M.H. Suur, P.J.C. van der Straaten, A.J. van der Heijden, R.N. Sukhai, K. Hählen, H.J. Neijens, R. de Groot

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Abstract

The antiinflammatory mediators interleukin (IL)-10 and soluble tumor necrosis factor (TNF) receptors p55 (sTNFR-55) and sTNFR-75 in cerebrospinal fluid (CSF) from 37 children with bacterial meningitis were studied. CSF concentrations of IL-10, sTNFR-55, and sTNFR-75 and of the proinflammatory cytokines TNF-alpha, IL-6, and IL-8 were markedly elevated and were, with the exception of the sTNFRs, significantly higher in CSF than in serum. CSF concentrations of sTNFR- 55 and sTNFR-75 were only associated positively with IL-10 levels. CSF glucose levels correlated highly with levels of IL-10, sTNFR-55, and sTNFR-75 and weakly with TNF-alpha and IL-6. Cytokine levels in CSF decreased rapidly, while sTNFR levels remained elevated for at least 24 h.
Original languageEnglish
Pages (from-to)1498-1502
JournalThe Journal of Infectious Diseases
Volume173
Issue number6
Publication statusPublished - 1996
Externally publishedYes

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    Kornelisse, R. F., Savelkoul, H. F. J., Mulder, P. H. G., Suur, M. H., van der Straaten, P. J. C., van der Heijden, A. J., ... de Groot, R. (1996). Interleukin-10 and soluble tumor necrosis factor receptors in cerebrospinal fluid of children with bacterial meningitis. The Journal of Infectious Diseases, 173(6), 1498-1502.