Interactions of blacktea polyphenols with human gut microbiota: implications for gut and cardiovascular health

J.P.M. van Duynhoven, E.E. Vaughan, F. van Dorsten, V. Gomez-Roldan, R. de Vos, J.J.M. Vervoort, J.J.J. van der Hooft, L. Roger, R. Draijer, D.M. Jacobs

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)

Abstract

Epidemiologic studies have convincingly associated consumption of black tea with reduced cardiovascular risk. Research on the bioactive molecules has traditionally been focused on polyphenols, such as catechins. Black tea polyphenols (BTPs), however, mainly consist of high-molecular-weight species that predominantly persist in the colon. There, they can undergo a wide range of bioconversions by the resident colonic microbiota but can in turn also modulate gut microbial diversity. The impact of BTPs on colon microbial composition can now be assessed by microbiomics technologies. Novel metabolomics platforms coupled to de novo identification are currently available to cover the large diversity of BTP bioconversions by the gut microbiota. Nutrikinetic modeling has been proven to be critical for defining nutritional phenotypes related to gut microbial bioconversion capacity. The bioactivity of circulating metabolites has been studied only to a certain extent. Bioassays dedicated to specific aspects of gut and cardiovascular health have been used, although often at physiologically irrelevant concentrations and with limited coverage of relevant metabolite classes and their conjugated forms. Evidence for cardiovascular benefits of BTPs points toward antiinflammatory and blood pressure–lowering properties and improvement in platelet and endothelial function for specific microbial bioconversion products. Clearly, more work is needed to fill in existing knowledge gaps and to assess the in vitro and in vivo bioactivity of known and newly identified BTP metabolites. It is also of interest to assess how phenotypic variation in gut microbial BTP bioconversion capacity relates to gut and cardiovascular health predisposition.
Original languageEnglish
Pages (from-to)1631S-1641S
JournalAmerican Journal of Clinical Nutrition
Volume98
Issue number6
DOIs
Publication statusPublished - 2013

Fingerprint

Polyphenols
Tea
Health
Colon
Metabolomics
Catechin
Microbiota
Gastrointestinal Microbiome
Biological Assay
Epidemiologic Studies
Anti-Inflammatory Agents
Blood Platelets
Molecular Weight
Technology
Phenotype
Research

Keywords

  • red wine/grape juice
  • density-lipoprotein oxidation
  • coronary-artery-disease
  • vein endothelial-cells
  • human fecal microbiota
  • in-vitro
  • phenolic-acids
  • green tea
  • ellagitannin metabolites
  • dietary polyphenols

Cite this

van Duynhoven, J.P.M. ; Vaughan, E.E. ; van Dorsten, F. ; Gomez-Roldan, V. ; de Vos, R. ; Vervoort, J.J.M. ; van der Hooft, J.J.J. ; Roger, L. ; Draijer, R. ; Jacobs, D.M. / Interactions of blacktea polyphenols with human gut microbiota: implications for gut and cardiovascular health. In: American Journal of Clinical Nutrition. 2013 ; Vol. 98, No. 6. pp. 1631S-1641S.
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abstract = "Epidemiologic studies have convincingly associated consumption of black tea with reduced cardiovascular risk. Research on the bioactive molecules has traditionally been focused on polyphenols, such as catechins. Black tea polyphenols (BTPs), however, mainly consist of high-molecular-weight species that predominantly persist in the colon. There, they can undergo a wide range of bioconversions by the resident colonic microbiota but can in turn also modulate gut microbial diversity. The impact of BTPs on colon microbial composition can now be assessed by microbiomics technologies. Novel metabolomics platforms coupled to de novo identification are currently available to cover the large diversity of BTP bioconversions by the gut microbiota. Nutrikinetic modeling has been proven to be critical for defining nutritional phenotypes related to gut microbial bioconversion capacity. The bioactivity of circulating metabolites has been studied only to a certain extent. Bioassays dedicated to specific aspects of gut and cardiovascular health have been used, although often at physiologically irrelevant concentrations and with limited coverage of relevant metabolite classes and their conjugated forms. Evidence for cardiovascular benefits of BTPs points toward antiinflammatory and blood pressure–lowering properties and improvement in platelet and endothelial function for specific microbial bioconversion products. Clearly, more work is needed to fill in existing knowledge gaps and to assess the in vitro and in vivo bioactivity of known and newly identified BTP metabolites. It is also of interest to assess how phenotypic variation in gut microbial BTP bioconversion capacity relates to gut and cardiovascular health predisposition.",
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Interactions of blacktea polyphenols with human gut microbiota: implications for gut and cardiovascular health. / van Duynhoven, J.P.M.; Vaughan, E.E.; van Dorsten, F.; Gomez-Roldan, V.; de Vos, R.; Vervoort, J.J.M.; van der Hooft, J.J.J.; Roger, L.; Draijer, R.; Jacobs, D.M.

In: American Journal of Clinical Nutrition, Vol. 98, No. 6, 2013, p. 1631S-1641S.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Interactions of blacktea polyphenols with human gut microbiota: implications for gut and cardiovascular health

AU - van Duynhoven, J.P.M.

AU - Vaughan, E.E.

AU - van Dorsten, F.

AU - Gomez-Roldan, V.

AU - de Vos, R.

AU - Vervoort, J.J.M.

AU - van der Hooft, J.J.J.

AU - Roger, L.

AU - Draijer, R.

AU - Jacobs, D.M.

PY - 2013

Y1 - 2013

N2 - Epidemiologic studies have convincingly associated consumption of black tea with reduced cardiovascular risk. Research on the bioactive molecules has traditionally been focused on polyphenols, such as catechins. Black tea polyphenols (BTPs), however, mainly consist of high-molecular-weight species that predominantly persist in the colon. There, they can undergo a wide range of bioconversions by the resident colonic microbiota but can in turn also modulate gut microbial diversity. The impact of BTPs on colon microbial composition can now be assessed by microbiomics technologies. Novel metabolomics platforms coupled to de novo identification are currently available to cover the large diversity of BTP bioconversions by the gut microbiota. Nutrikinetic modeling has been proven to be critical for defining nutritional phenotypes related to gut microbial bioconversion capacity. The bioactivity of circulating metabolites has been studied only to a certain extent. Bioassays dedicated to specific aspects of gut and cardiovascular health have been used, although often at physiologically irrelevant concentrations and with limited coverage of relevant metabolite classes and their conjugated forms. Evidence for cardiovascular benefits of BTPs points toward antiinflammatory and blood pressure–lowering properties and improvement in platelet and endothelial function for specific microbial bioconversion products. Clearly, more work is needed to fill in existing knowledge gaps and to assess the in vitro and in vivo bioactivity of known and newly identified BTP metabolites. It is also of interest to assess how phenotypic variation in gut microbial BTP bioconversion capacity relates to gut and cardiovascular health predisposition.

AB - Epidemiologic studies have convincingly associated consumption of black tea with reduced cardiovascular risk. Research on the bioactive molecules has traditionally been focused on polyphenols, such as catechins. Black tea polyphenols (BTPs), however, mainly consist of high-molecular-weight species that predominantly persist in the colon. There, they can undergo a wide range of bioconversions by the resident colonic microbiota but can in turn also modulate gut microbial diversity. The impact of BTPs on colon microbial composition can now be assessed by microbiomics technologies. Novel metabolomics platforms coupled to de novo identification are currently available to cover the large diversity of BTP bioconversions by the gut microbiota. Nutrikinetic modeling has been proven to be critical for defining nutritional phenotypes related to gut microbial bioconversion capacity. The bioactivity of circulating metabolites has been studied only to a certain extent. Bioassays dedicated to specific aspects of gut and cardiovascular health have been used, although often at physiologically irrelevant concentrations and with limited coverage of relevant metabolite classes and their conjugated forms. Evidence for cardiovascular benefits of BTPs points toward antiinflammatory and blood pressure–lowering properties and improvement in platelet and endothelial function for specific microbial bioconversion products. Clearly, more work is needed to fill in existing knowledge gaps and to assess the in vitro and in vivo bioactivity of known and newly identified BTP metabolites. It is also of interest to assess how phenotypic variation in gut microbial BTP bioconversion capacity relates to gut and cardiovascular health predisposition.

KW - red wine/grape juice

KW - density-lipoprotein oxidation

KW - coronary-artery-disease

KW - vein endothelial-cells

KW - human fecal microbiota

KW - in-vitro

KW - phenolic-acids

KW - green tea

KW - ellagitannin metabolites

KW - dietary polyphenols

U2 - 10.3945/ajcn.113.058263

DO - 10.3945/ajcn.113.058263

M3 - Article

VL - 98

SP - 1631S-1641S

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 6

ER -