Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism

D.C. Liemburg-Apers, P.H.G.M. Willems, W.J.H. Koopman, Sander Grefte

Research output: Contribution to journalArticleAcademicpeer-review

118 Citations (Scopus)

Abstract

Mitochondrial reactive oxygen species (ROS) production and detoxification are tightly balanced. Shifting this balance enables ROS to activate intracellular signaling and/or induce cellular damage and cell death. Increased mitochondrial ROS production is observed in a number of pathological conditions characterized by mitochondrial dysfunction. One important hallmark of these diseases is enhanced glycolytic activity and low or impaired oxidative phosphorylation. This suggests that ROS is involved in glycolysis (dys)regulation and vice versa. Here we focus on the bidirectional link between ROS and the regulation of glucose metabolism. To this end, we provide a basic introduction into mitochondrial energy metabolism, ROS generation and redox homeostasis. Next, we discuss the interactions between cellular glucose metabolism and ROS. ROS-stimulated cellular glucose uptake can stimulate both ROS production and scavenging. When glucose-stimulated ROS production, leading to further glucose uptake, is not adequately counterbalanced by (glucose-stimulated) ROS scavenging systems, a toxic cycle is triggered, ultimately leading to cell death. Here we inventoried the various cellular regulatory mechanisms and negative feedback loops that prevent this cycle from occurring. It is concluded that more insight in these processes is required to understand why they are (un)able to prevent excessive ROS production during various pathological conditions in humans.

Original languageEnglish
Pages (from-to)1209-1226
JournalArchives of Toxicology
Volume89
Issue number8
DOIs
Publication statusPublished - 6 Jun 2015

Keywords

  • Glucose
  • GLUT1
  • GLUT4
  • Mitochondria
  • Oxidative stress
  • ROS

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