Interactions between five candidate genes and antihypertensive drug therapy on blood pressure

H. Schelleman, B.H.C. Stricker, W.M.M. Verschuren, A. de Boer, A.A. Kroon, P.W. de Leeuw, D. Kromhout, O.H. Klungel

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Abstract

Despite the availability of effective antihypertensive drugs, there is a large variation in response to these drugs. This study investigates whether polymorphisms in the angiotensin converting enzyme (I/D), angiotensinogen (M235T), -adducin (G460W), angiotensin II type 1 receptor (1166A/C), or G protein 3-subunit (825C/T) gene modify the mean difference in blood pressure levels among diuretics, -blockers, or ACE-inhibitors users. Data were used from the Doetinchem Cohort Study, and blood pressure data were collected from GPs (1987¿1997). A marginal generalized linear model (GEE) was used to assess the gene¿drug interaction on the mean difference in systolic/diastolic blood pressure. In total, 625 hypertensive individuals were included with a total of 5262 measurements of blood pressure. Only the interaction between diuretic use and the GNB3 825C/T polymorphism was significant (C allele versus TT systolic blood pressure (SBP): 4.33 mmHg [95% CI: 0.14¿8.54]). Thus, the mean SBP level among diuretic users may be modified by the GNB3 825C/T polymorphism
Original languageEnglish
Pages (from-to)22-26
JournalThe Pharmacogenomics Journal
Volume6
Issue number1
DOIs
Publication statusPublished - 2006

Keywords

  • hypertension
  • polymorphisms
  • angiotensinogen
  • association
  • allele

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    Schelleman, H., Stricker, B. H. C., Verschuren, W. M. M., de Boer, A., Kroon, A. A., de Leeuw, P. W., Kromhout, D., & Klungel, O. H. (2006). Interactions between five candidate genes and antihypertensive drug therapy on blood pressure. The Pharmacogenomics Journal, 6(1), 22-26. https://doi.org/10.1038/sj.tpj.6500339