Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine

Katja C.W. van Dongen; Clara Belzer; Wouter Bakker; Ivonne M.C.M. Rietjens; Karsten Beekmann

doi:10.1021/acs.jafc.2c05756

Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine

Katja C.W. van Dongen^*, Clara Belzer, Wouter Bakker, Ivonne M.C.M. Rietjens, Karsten Beekmann

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

The advanced glycation endproduct carboxymethyllysine and its precursor fructoselysine are present in heated, processed food products and are considered potentially hazardous for human health. Upon dietary exposure, they can be degraded by human colonic gut microbiota, reducing internal exposure. Pronounced interindividual and intraindividual differences in these metabolic degradations were found in anaerobic incubations with human fecal slurries in vitro. The average capacity to degrade fructoselysine was 27.7-fold higher than that for carboxymethyllysine, and degradation capacities for these two compounds were not correlated (R2 = 0.08). Analysis of the bacterial composition revealed that interindividual differences outweighed intraindividual differences, and multiple genera were correlated with the individuals' carboxymethyllysine and fructoselysine degradation capacities (e.g., Akkermansia, Alistipes).

Original language	English
Pages (from-to)	11759-11768
Journal	Journal of Agricultural and Food Chemistry
Volume	70
Issue number	37
DOIs	https://doi.org/10.1021/acs.jafc.2c05756
Publication status	Published - 21 Sept 2022

Keywords

16S rRNA analysis
advanced glycation end product
human gut microbiota
interindividual differences
intraindividual differences
new approach methodologies
temporal variability

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.jafc.2c05756Licence: CC BY

https://edepot.wur.nl/578434Licence: CC BY

VLAG AIO gut microbiome chip (KB-37-002-020, KB-23-002-036)
van der Zande, M. (Project Leader)
1/01/18 → 31/12/22
Project: LVVN project

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@article{a1dd913ae3534a8bad27893bbba83203,

title = "Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine",

abstract = "The advanced glycation endproduct carboxymethyllysine and its precursor fructoselysine are present in heated, processed food products and are considered potentially hazardous for human health. Upon dietary exposure, they can be degraded by human colonic gut microbiota, reducing internal exposure. Pronounced interindividual and intraindividual differences in these metabolic degradations were found in anaerobic incubations with human fecal slurries in vitro. The average capacity to degrade fructoselysine was 27.7-fold higher than that for carboxymethyllysine, and degradation capacities for these two compounds were not correlated (R2 = 0.08). Analysis of the bacterial composition revealed that interindividual differences outweighed intraindividual differences, and multiple genera were correlated with the individuals' carboxymethyllysine and fructoselysine degradation capacities (e.g., Akkermansia, Alistipes).",

keywords = "16S rRNA analysis, advanced glycation end product, human gut microbiota, interindividual differences, intraindividual differences, new approach methodologies, temporal variability",

author = "{van Dongen}, {Katja C.W.} and Clara Belzer and Wouter Bakker and Rietjens, {Ivonne M.C.M.} and Karsten Beekmann",

year = "2022",

month = sep,

day = "21",

doi = "10.1021/acs.jafc.2c05756",

language = "English",

volume = "70",

pages = "11759--11768",

journal = "Journal of Agricultural and Food Chemistry",

issn = "0021-8561",

publisher = "American Chemical Society",

number = "37",

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Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine. / van Dongen, Katja C.W.; Belzer, Clara ; Bakker, Wouter et al.
In: Journal of Agricultural and Food Chemistry, Vol. 70, No. 37, 21.09.2022, p. 11759-11768.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine

AU - van Dongen, Katja C.W.

AU - Belzer, Clara

AU - Bakker, Wouter

AU - Rietjens, Ivonne M.C.M.

AU - Beekmann, Karsten

PY - 2022/9/21

Y1 - 2022/9/21

N2 - The advanced glycation endproduct carboxymethyllysine and its precursor fructoselysine are present in heated, processed food products and are considered potentially hazardous for human health. Upon dietary exposure, they can be degraded by human colonic gut microbiota, reducing internal exposure. Pronounced interindividual and intraindividual differences in these metabolic degradations were found in anaerobic incubations with human fecal slurries in vitro. The average capacity to degrade fructoselysine was 27.7-fold higher than that for carboxymethyllysine, and degradation capacities for these two compounds were not correlated (R2 = 0.08). Analysis of the bacterial composition revealed that interindividual differences outweighed intraindividual differences, and multiple genera were correlated with the individuals' carboxymethyllysine and fructoselysine degradation capacities (e.g., Akkermansia, Alistipes).

AB - The advanced glycation endproduct carboxymethyllysine and its precursor fructoselysine are present in heated, processed food products and are considered potentially hazardous for human health. Upon dietary exposure, they can be degraded by human colonic gut microbiota, reducing internal exposure. Pronounced interindividual and intraindividual differences in these metabolic degradations were found in anaerobic incubations with human fecal slurries in vitro. The average capacity to degrade fructoselysine was 27.7-fold higher than that for carboxymethyllysine, and degradation capacities for these two compounds were not correlated (R2 = 0.08). Analysis of the bacterial composition revealed that interindividual differences outweighed intraindividual differences, and multiple genera were correlated with the individuals' carboxymethyllysine and fructoselysine degradation capacities (e.g., Akkermansia, Alistipes).

KW - 16S rRNA analysis

KW - advanced glycation end product

KW - human gut microbiota

KW - interindividual differences

KW - intraindividual differences

KW - new approach methodologies

KW - temporal variability

U2 - 10.1021/acs.jafc.2c05756

DO - 10.1021/acs.jafc.2c05756

M3 - Article

C2 - 36069406

AN - SCOPUS:85138458178

SN - 0021-8561

VL - 70

SP - 11759

EP - 11768

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

IS - 37

ER -

Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine

Abstract

Keywords

UN SDGs

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Projects

VLAG AIO gut microbiome chip (KB-37-002-020, KB-23-002-036)

Cite this