Intelligent system design for bionanorobots in drug delivery

Mark Fletcher, Mohammad Biglarbegian, Suresh Neethirajan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)


A nanorobot is defined as any smart structure which is capable of actuation, sensing, manipulation, intelligence, and swarm behavior at the nanoscale. In this study, we designed an intelligent system using fuzzy logic for diagnosis and treatment of tumors inside the human body using bionanorobots. We utilize fuzzy logic and a combination of thermal, magnetic, optical, and chemical nanosensors to interpret the uncertainty associated with the sensory information. Two different fuzzy logic structures, for diagnosis (Mamdani structure) and for cure (Takagi-Sugeno structure), were developed to efficiently identify the tumors and treat them through delivery of effective dosages of a drug. Validation of the designed system with simulated conditions proved that the drug delivery of bionanorobots was robust to reasonable noise that may occur in the bionanorobot sensors during navigation, diagnosis, and curing of the cancer cells. Bionanorobots represent a great hope for successful cancer therapy in the near future.

Original languageEnglish
Pages (from-to)117-125
Number of pages9
JournalCancer Nanotechnology
Issue number4-5
Publication statusPublished - 14 Jul 2013
Externally publishedYes


  • Bionanorobot
  • Control system
  • Drug delivery
  • Fuzzy logic
  • Nanomedicine


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