Integrated safety assessment (ISA) of food products

    Research output: Chapter in Book/Report/Conference proceedingAbstractAcademic


    Safety assessment of novel and complex food products or food ingredients remains a complicated task. Classical approaches are debated, alternative approaches not accepted yet. Clearly for complex foods and mixtures, in vivo tests are not providing the answers needed to scientifically underpin the safety assessment. An integrated testing strategy (ITS) combining computational toxicology,in vitro cell systems, and sensitive adverse outcome pathway effect analysis is emerging as a promising approach for risk assessment of chemicals. However, complex products provide an additional challenge due to the large variety of components present, the majority of which are harmless. By extending the toxicological integrated testing strategy with compositional analysis (analytical profiling us-ing various omics approaches), biotransformation, and effect based identification (bio-MS) of hazardous components, we aim to create an integrated safety assessment (ISA) strategy for complex (food) products. By combining these tools we create an experimental platform for collecting and generating safety data. The resulting platform is flexible and may occasionally also comprise animal feeding trials, but given the advancements in informative analytical, in silico and in vitro methodologies, this should be determined case by case rather than obligatory for the approval of novel food products or food ingredients in general.
    Original languageEnglish
    Title of host publicationALTEX Proceedings
    Publication statusPublished - 2014
    Event9th World Congress on Alternatives and Animal Use in the life Sciences, Prague, Czech Republic -
    Duration: 24 Aug 201428 Aug 2014


    Conference9th World Congress on Alternatives and Animal Use in the life Sciences, Prague, Czech Republic


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