Background: High intake of fish and marine n-3 polyunsaturated fatty acids (PUFAs) may protect against age-related cognitive decline. However, results are inconsistent and limited data exist regarding changes in multiple cognitive functions over a longer period of time. Objective: To assess the association between fatty fish as well as marine n-3 PUFA (EPA-DHA) intake with cognitive performance and cognitive change over 6 years in 1025 elderly men. Design: Participants were from the US Veterans Affairs Normative Aging Study (NAS). Cognitive function was assessed with a battery of cognitive tests focusing on the factors memory/language, speed and visuospatial/attention. Dietary intakes were assessed with a food frequency questionnaire. General linear models were used to assess cross-sectional associations and mixed models were used to assess the associations over time. Models were adjusted for age, education (model 1) and also for BMI, smoking, diabetes, and intake of alcohol, saturated fat, vitamin C and vitamin E (model 2). Results: Mean age of the participating men was 68 years at baseline. Median fish consumption ranged from 0.7 to 4.2 portions per week over the quartiles. Cross-sectional analyses showed no association between fatty fish or EPA-DHA intake and cognitive performance. Also over 6 years of follow-up we did not observe any significant associations between fatty fish or EPA-DHA intake and cognitive change. Conclusions: In this population of elderly men, higher intake of fatty fish or EPA-DHA was neither associated with cognitive performance nor with 6-year cognitive change
|Pages (from-to)||S21 (P49)-S21|
|Journal||European Journal of Clinical Nutrition|
|Publication status||Published - 2009|
van de Rest, O., Spiro, A., Krall Kaye, E., Geleijnse, J. M., de Groot, C. P. G. M., & Tucker, K. L. (2009). Intake of fatty fish and n-3 fatty acids intake in relation to cognitive performance and 6 year cognitive change in ageing men: the Veterans Affairs Normative Aging Study. European Journal of Clinical Nutrition, 63(S3), S21 (P49)-S21.