Insoluble dietary fibre scavenges reactive carbonyl species under simulated physiological conditions: The key role of fibre-bound polyphenols

Hao Zhang, Antonio Dario Troise, Yajing Qi, Gangcheng Wu, Hui Zhang*, Vincenzo Fogliano

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Abstract

Polyphenols bound to insoluble fibre may scavenge reactive carbonyl species by surface chemical reactions. In the present study, this hypothesis was tested by investigating the ability of bound-polyphenol rich insoluble dietary fibre (BP-IDF) isolated from blackberry pomace, red cabbage, and wheat bran in scavenging carbonyl compounds. Three BP-IDF showed high scavenging efficacy for glyoxal, methylglyoxal, acrolein and malondialdehyde. Upon in vitro digestion, trapping capacity was retained by the insoluble fraction suggesting that carbonyl trapping activity and physiological relevance needs to be extended to undigestible materials. The removal of bound polyphenols from the polysaccharide backbones through alkaline and acidic treatment reduced by up to 90% of trapping capacity of BP-IDF. Moreover, methylglyoxal-polyphenol adducts were detected bound to blackberry pomace BP-IDF after hydrolysis. These findings demonstrated that polyphenols bound to IDF scavenged reactive carbonyl species and highlighted the physiological relevance of BP-IDF in limiting carbonyl stress along all the gastrointestinal tract.

Original languageEnglish
Article number129018
JournalFood Chemistry
Volume349
DOIs
Publication statusPublished - 1 Jul 2021

Keywords

  • Bound polyphenols
  • Insoluble dietary fibre
  • Reactive carbonyl compounds
  • Scavenging activity

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