TY - JOUR
T1 - Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment
AU - Tkalec, Žiga
AU - Antignac, Jean Philippe
AU - Bandow, Nicole
AU - Béen, Frederic M.
AU - Belova, Lidia
AU - Bessems, Jos
AU - Le Bizec, Bruno
AU - Brack, Werner
AU - Cano-Sancho, German
AU - Chaker, Jade
AU - Covaci, Adrian
AU - Creusot, Nicolas
AU - David, Arthur
AU - Debrauwer, Laurent
AU - Dervilly, Gaud
AU - Duca, Radu Corneliu
AU - Fessard, Valérie
AU - Grimalt, Joan O.
AU - Guerin, Thierry
AU - Habchi, Baninia
AU - Hecht, Helge
AU - Hollender, Juliane
AU - Jamin, Emilien L.
AU - Klánová, Jana
AU - Kosjek, Tina
AU - Krauss, Martin
AU - Lamoree, Marja
AU - Lavison-Bompard, Gwenaelle
AU - Meijer, Jeroen
AU - Moeller, Ruth
AU - Mol, Hans
AU - Mompelat, Sophie
AU - Van Nieuwenhuyse, An
AU - Oberacher, Herbert
AU - Parinet, Julien
AU - Van Poucke, Christof
AU - Roškar, Robert
AU - Togola, Anne
AU - Trontelj, Jurij
AU - Price, Elliott J.
PY - 2024/4
Y1 - 2024/4
N2 - The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment.
AB - The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment.
KW - Chemical exposure
KW - Chemical risk assessment
KW - Effect-based methods
KW - Effect-directed analysis
KW - High-resolution mass spectrometry
KW - Sampling strategies
U2 - 10.1016/j.envint.2024.108585
DO - 10.1016/j.envint.2024.108585
M3 - Article
AN - SCOPUS:85188785915
SN - 0160-4120
VL - 186
JO - Environment International
JF - Environment International
M1 - 108585
ER -
