This study shows the effectiveness of vaccination with an E2 subunit vaccine against classical swine fever (CSF) in 2-week-old piglets. Half of the piglets were carrying maternally derived antibodies (MDAs) at the time of vaccination. Three and 6 months later, antibody levels were compared between the two treatments. Moreover, reduction of virus transmission was investigated at 3 and 6 months by doing transmission experiments. The vaccine was found to be capable of reducing virus transmission significantly at both time intervals. Maternal immunity reduced vaccination-induced antibody levels after 3 and 6 months and possibly led to a less effective protection against virus transmission after 6 months.
- marker vaccine
- pseudorabies virus
- 1997-1998 epidemic
- pregnant sows
Klinkenberg, D., Moormann, R. J. M., de Smit, A. J., Bouma, A., & de Jong, M. C. M. (2002). Influence of maternal antibodies on efficacy of a subunit vaccine: transmission of classical swine fever virus between pigs vaccinated at 2 weeks of age. Vaccine, 20(23-24), 3005-3013. https://doi.org/10.1016/S0042-207X(02)00283-X