Influence of maternal antibodies on efficacy of a subunit vaccine: transmission of classical swine fever virus between pigs vaccinated at 2 weeks of age

D. Klinkenberg, R.J.M. Moormann, A.J. de Smit, A. Bouma, M.C.M. de Jong

    Research output: Contribution to journalArticleAcademicpeer-review

    28 Citations (Scopus)

    Abstract

    This study shows the effectiveness of vaccination with an E2 subunit vaccine against classical swine fever (CSF) in 2-week-old piglets. Half of the piglets were carrying maternally derived antibodies (MDAs) at the time of vaccination. Three and 6 months later, antibody levels were compared between the two treatments. Moreover, reduction of virus transmission was investigated at 3 and 6 months by doing transmission experiments. The vaccine was found to be capable of reducing virus transmission significantly at both time intervals. Maternal immunity reduced vaccination-induced antibody levels after 3 and 6 months and possibly led to a less effective protection against virus transmission after 6 months.
    Original languageEnglish
    Pages (from-to)3005-3013
    JournalVaccine
    Volume20
    Issue number23-24
    DOIs
    Publication statusPublished - 2002

    Keywords

    • marker vaccine
    • pseudorabies virus
    • 1997-1998 epidemic
    • pregnant sows
    • e2
    • netherlands
    • immunity
    • protection
    • strategies
    • disease

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