Influence of applying different units of measurement on reporting antimicrobial consumption data for pig farms

F.J. Taverne, J.H. Jacobs, D.J.J. Heederik, J.W. Mouton, J.A. Wagenaar, I.M. van Geijlswijk

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Background: Antimicrobial use in livestock is one of the factors contributing to selection and spread of resistant microorganisms in the environment. National veterinary antimicrobial consumption monitoring programs are therefore in place in a number of countries in the European Union. However, due to differences in methodology, results on veterinary antimicrobial consumption from these national monitoring programs cannot be compared internationally. International comparison is highly needed to establish regulations on veterinary antimicrobial use and reducing antimicrobial resistance. The aim of this study was to assess differences in the outcomes on veterinary antimicrobial consumption by applying three different sets of nationally established animal defined daily dosages to the same antimicrobial drug delivery dataset of Dutch pigs in 2012. Methods: Delivery information for the complete Dutch pig sector for the year 2012 reported to the Netherlands Veterinary Medicines Authority (SDa) was analysed with three differently and nationally established animal defined daily dosages from the Netherlands and Denmark: the Defined Daily Dosage AnimalNL (DDDANL), the Animal Daily DosageDK (ADDDK) and Defined Animal Daily DosageDK (DADDDK). For each applied Dutch product equivalent, Danish products were identified based on authorization for pigs, active substance (including form), administration route, concentration and dosage regimen. Results: Consumption in number of ADDDK/Y was lower than in number of DDDANL/Y for sows/piglets and finisher pigs, with proportions of 83.3 % and 98.3 %. Use in number of DADDDK/Y was even lower, 79.7 % for sows/piglets and 88.1 % for finisher pigs compared to number of DDDANL/Y. At therapeutic group level proportions of number of DADDDK/Y to number of DDDANL/Y were 63.6-150.4 % (sows/piglets) and 55.6-171.0 % (finisher pigs). Proportions were > 100 % for the polymyxines (sows/piglets 150.4 % and finisher pigs 149.9 %) and the macrolides/lincosamides (finisher pigs 171.0 %). Conclusions: Differences between nationally established animal defined daily dosages caused by different correction factors for long-acting products and national differences in authorized dosages, have a substantial influence on the results of antimicrobial consumption in pigs. To enable international comparison of veterinary antimicrobial consumption data, harmonized units of measurement, animal weights and animal (sub) categories are needed.

Original languageEnglish
Article number250
Number of pages9
JournalBMC Veterinary Research
Volume11
DOIs
Publication statusPublished - 2015

Fingerprint

Swine
anti-infective agents
farms
swine
dosage
animals
sows
piglets
Netherlands
Lincosamides
Farms
macrolides
Veterinary Medicine
monitoring
Macrolides
Livestock
European Union
Denmark
antibiotic resistance
veterinary medicine

Keywords

  • Antimicrobial consumption monitoring
  • Daily dosages
  • International
  • Livestock
  • Methodology
  • Veterinary medicine

Cite this

Taverne, F. J., Jacobs, J. H., Heederik, D. J. J., Mouton, J. W., Wagenaar, J. A., & van Geijlswijk, I. M. (2015). Influence of applying different units of measurement on reporting antimicrobial consumption data for pig farms. BMC Veterinary Research, 11, [250]. https://doi.org/10.1186/s12917-015-0566-7
Taverne, F.J. ; Jacobs, J.H. ; Heederik, D.J.J. ; Mouton, J.W. ; Wagenaar, J.A. ; van Geijlswijk, I.M. / Influence of applying different units of measurement on reporting antimicrobial consumption data for pig farms. In: BMC Veterinary Research. 2015 ; Vol. 11.
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title = "Influence of applying different units of measurement on reporting antimicrobial consumption data for pig farms",
abstract = "Background: Antimicrobial use in livestock is one of the factors contributing to selection and spread of resistant microorganisms in the environment. National veterinary antimicrobial consumption monitoring programs are therefore in place in a number of countries in the European Union. However, due to differences in methodology, results on veterinary antimicrobial consumption from these national monitoring programs cannot be compared internationally. International comparison is highly needed to establish regulations on veterinary antimicrobial use and reducing antimicrobial resistance. The aim of this study was to assess differences in the outcomes on veterinary antimicrobial consumption by applying three different sets of nationally established animal defined daily dosages to the same antimicrobial drug delivery dataset of Dutch pigs in 2012. Methods: Delivery information for the complete Dutch pig sector for the year 2012 reported to the Netherlands Veterinary Medicines Authority (SDa) was analysed with three differently and nationally established animal defined daily dosages from the Netherlands and Denmark: the Defined Daily Dosage AnimalNL (DDDANL), the Animal Daily DosageDK (ADDDK) and Defined Animal Daily DosageDK (DADDDK). For each applied Dutch product equivalent, Danish products were identified based on authorization for pigs, active substance (including form), administration route, concentration and dosage regimen. Results: Consumption in number of ADDDK/Y was lower than in number of DDDANL/Y for sows/piglets and finisher pigs, with proportions of 83.3 {\%} and 98.3 {\%}. Use in number of DADDDK/Y was even lower, 79.7 {\%} for sows/piglets and 88.1 {\%} for finisher pigs compared to number of DDDANL/Y. At therapeutic group level proportions of number of DADDDK/Y to number of DDDANL/Y were 63.6-150.4 {\%} (sows/piglets) and 55.6-171.0 {\%} (finisher pigs). Proportions were > 100 {\%} for the polymyxines (sows/piglets 150.4 {\%} and finisher pigs 149.9 {\%}) and the macrolides/lincosamides (finisher pigs 171.0 {\%}). Conclusions: Differences between nationally established animal defined daily dosages caused by different correction factors for long-acting products and national differences in authorized dosages, have a substantial influence on the results of antimicrobial consumption in pigs. To enable international comparison of veterinary antimicrobial consumption data, harmonized units of measurement, animal weights and animal (sub) categories are needed.",
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author = "F.J. Taverne and J.H. Jacobs and D.J.J. Heederik and J.W. Mouton and J.A. Wagenaar and {van Geijlswijk}, I.M.",
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Influence of applying different units of measurement on reporting antimicrobial consumption data for pig farms. / Taverne, F.J.; Jacobs, J.H.; Heederik, D.J.J.; Mouton, J.W.; Wagenaar, J.A.; van Geijlswijk, I.M.

In: BMC Veterinary Research, Vol. 11, 250, 2015.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Influence of applying different units of measurement on reporting antimicrobial consumption data for pig farms

AU - Taverne, F.J.

AU - Jacobs, J.H.

AU - Heederik, D.J.J.

AU - Mouton, J.W.

AU - Wagenaar, J.A.

AU - van Geijlswijk, I.M.

PY - 2015

Y1 - 2015

N2 - Background: Antimicrobial use in livestock is one of the factors contributing to selection and spread of resistant microorganisms in the environment. National veterinary antimicrobial consumption monitoring programs are therefore in place in a number of countries in the European Union. However, due to differences in methodology, results on veterinary antimicrobial consumption from these national monitoring programs cannot be compared internationally. International comparison is highly needed to establish regulations on veterinary antimicrobial use and reducing antimicrobial resistance. The aim of this study was to assess differences in the outcomes on veterinary antimicrobial consumption by applying three different sets of nationally established animal defined daily dosages to the same antimicrobial drug delivery dataset of Dutch pigs in 2012. Methods: Delivery information for the complete Dutch pig sector for the year 2012 reported to the Netherlands Veterinary Medicines Authority (SDa) was analysed with three differently and nationally established animal defined daily dosages from the Netherlands and Denmark: the Defined Daily Dosage AnimalNL (DDDANL), the Animal Daily DosageDK (ADDDK) and Defined Animal Daily DosageDK (DADDDK). For each applied Dutch product equivalent, Danish products were identified based on authorization for pigs, active substance (including form), administration route, concentration and dosage regimen. Results: Consumption in number of ADDDK/Y was lower than in number of DDDANL/Y for sows/piglets and finisher pigs, with proportions of 83.3 % and 98.3 %. Use in number of DADDDK/Y was even lower, 79.7 % for sows/piglets and 88.1 % for finisher pigs compared to number of DDDANL/Y. At therapeutic group level proportions of number of DADDDK/Y to number of DDDANL/Y were 63.6-150.4 % (sows/piglets) and 55.6-171.0 % (finisher pigs). Proportions were > 100 % for the polymyxines (sows/piglets 150.4 % and finisher pigs 149.9 %) and the macrolides/lincosamides (finisher pigs 171.0 %). Conclusions: Differences between nationally established animal defined daily dosages caused by different correction factors for long-acting products and national differences in authorized dosages, have a substantial influence on the results of antimicrobial consumption in pigs. To enable international comparison of veterinary antimicrobial consumption data, harmonized units of measurement, animal weights and animal (sub) categories are needed.

AB - Background: Antimicrobial use in livestock is one of the factors contributing to selection and spread of resistant microorganisms in the environment. National veterinary antimicrobial consumption monitoring programs are therefore in place in a number of countries in the European Union. However, due to differences in methodology, results on veterinary antimicrobial consumption from these national monitoring programs cannot be compared internationally. International comparison is highly needed to establish regulations on veterinary antimicrobial use and reducing antimicrobial resistance. The aim of this study was to assess differences in the outcomes on veterinary antimicrobial consumption by applying three different sets of nationally established animal defined daily dosages to the same antimicrobial drug delivery dataset of Dutch pigs in 2012. Methods: Delivery information for the complete Dutch pig sector for the year 2012 reported to the Netherlands Veterinary Medicines Authority (SDa) was analysed with three differently and nationally established animal defined daily dosages from the Netherlands and Denmark: the Defined Daily Dosage AnimalNL (DDDANL), the Animal Daily DosageDK (ADDDK) and Defined Animal Daily DosageDK (DADDDK). For each applied Dutch product equivalent, Danish products were identified based on authorization for pigs, active substance (including form), administration route, concentration and dosage regimen. Results: Consumption in number of ADDDK/Y was lower than in number of DDDANL/Y for sows/piglets and finisher pigs, with proportions of 83.3 % and 98.3 %. Use in number of DADDDK/Y was even lower, 79.7 % for sows/piglets and 88.1 % for finisher pigs compared to number of DDDANL/Y. At therapeutic group level proportions of number of DADDDK/Y to number of DDDANL/Y were 63.6-150.4 % (sows/piglets) and 55.6-171.0 % (finisher pigs). Proportions were > 100 % for the polymyxines (sows/piglets 150.4 % and finisher pigs 149.9 %) and the macrolides/lincosamides (finisher pigs 171.0 %). Conclusions: Differences between nationally established animal defined daily dosages caused by different correction factors for long-acting products and national differences in authorized dosages, have a substantial influence on the results of antimicrobial consumption in pigs. To enable international comparison of veterinary antimicrobial consumption data, harmonized units of measurement, animal weights and animal (sub) categories are needed.

KW - Antimicrobial consumption monitoring

KW - Daily dosages

KW - International

KW - Livestock

KW - Methodology

KW - Veterinary medicine

U2 - 10.1186/s12917-015-0566-7

DO - 10.1186/s12917-015-0566-7

M3 - Article

VL - 11

JO - BMC Veterinary Research

JF - BMC Veterinary Research

SN - 1746-6148

M1 - 250

ER -