Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines

E.D. Geus, de, J.M.J. Rebel, L. Vervelde

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

The risk and the size of an outbreak of avian influenza virus (AIV) could be restricted by vaccination of poultry. A vaccine used for rapid intervention during an AIV outbreak should be safe, highly effective after a single administration and suitable for mass application. In the case of AIV, aerosol vaccination using live virus is not desirable because of its zoonotic potential and because of the risk for virus reassortment. The rational design of novel mucosal-inactivated vaccines against AIV requires a comprehensive knowledge of the structure and function of the lung-associated immune system in birds in order to target vaccines appropriately and to design efficient mucosal adjuvants. This review addresses our current understanding of the induction of respiratory immune responses in the chicken. Furthermore, possible mucosal vaccination strategies for AIV are highlighted.
Original languageEnglish
Pages (from-to)75-86
JournalVeterinary Quarterly
Volume32
Issue number2
DOIs
Publication statusPublished - 2012

Keywords

  • infectious-bronchitis virus
  • newcastle-disease vaccine
  • cell-mediated-immunity
  • controls phagosomal ph
  • memory b-cells
  • dendritic cells
  • lymphoid-tissue
  • harderian-gland
  • plasma-cells
  • mycoplasma-gallisepticum

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