Induction and regulation of allergen-specific IgE

P.V. Jeurink, H.F.J. Savelkoul

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The immune response is characterized by an initial rapid activation of the innate defence system, geared at recognizing common structures shared by many microorganisms. This innate immune response is a prerequisite to mount a highly antigenspecific adaptive immune response consisting of T-cell differentiation into effector subsets and B-cell differentiation into antibody-secreting plasma cells. Commonly, allergy is characterized by dendritic cells presenting allergenic peptides, activated Th2 cells producing signature cytokines like IL-4 and IL-5, and B-cells producing allergen-specific IgE antibodies. Under non-allergic conditions tolerance mechanisms, comprising regulatory T-cell subsets, are suppressing potential immune responses to allergen exposure. The protein structure of many allergens has been resolved and has provided an explanation for the epitope-specific IgE cross-reactivity responsible for the pollen food syndrome. The knowledge on the protein characteristics of the major food allergens can provide better understanding why certain types of allergic symptoms can develop in particular individuals. Together with information on the genetic basis and the modulatory capacity of the environment, the Allergy Consortium Wageningen sets out to develop preventive measures to reduce allergic sensitization, to give advice to reduce allergen exposure and induce symptom reduction, and to provide clues to the management of an existing allergy.
Original languageEnglish
Title of host publicationAllergy Matters : new approaches to allergy prevention and management
EditorsL.J.E.J. Dr. Gilissen, H.J. Prof.dr. Wichers, H.F.J. Prof.dr.ir. Savelkoul, R.J. Bogers
Pages13-27
Number of pages205
Publication statusPublished - 2005

Publication series

NameWageningen UR Frontis Series
PublisherSpringer - Life Sciences
Number10

Fingerprint

Allergens
Immunoglobulin E
Hypersensitivity
Cell Differentiation
B-Lymphocyte Subsets
Food
Antibody-Producing Cells
Th2 Cells
Interleukin-5
T-Lymphocyte Subsets
Adaptive Immunity
Regulatory T-Lymphocytes
Pollen
Plasma Cells
Innate Immunity
Interleukin-4
Dendritic Cells
Epitopes
Proteins
B-Lymphocytes

Cite this

Jeurink, P. V., & Savelkoul, H. F. J. (2005). Induction and regulation of allergen-specific IgE. In L. J. E. J. Dr. Gilissen, H. J. Prof.dr. Wichers, H. F. J. Prof.dr.ir. Savelkoul, & R. J. Bogers (Eds.), Allergy Matters : new approaches to allergy prevention and management (pp. 13-27). (Wageningen UR Frontis Series; No. 10).
Jeurink, P.V. ; Savelkoul, H.F.J. / Induction and regulation of allergen-specific IgE. Allergy Matters : new approaches to allergy prevention and management. editor / L.J.E.J. Dr. Gilissen ; H.J. Prof.dr. Wichers ; H.F.J. Prof.dr.ir. Savelkoul ; R.J. Bogers. 2005. pp. 13-27 (Wageningen UR Frontis Series; 10).
@inbook{3897d34451e54f0b956ae7c44b83394d,
title = "Induction and regulation of allergen-specific IgE",
abstract = "The immune response is characterized by an initial rapid activation of the innate defence system, geared at recognizing common structures shared by many microorganisms. This innate immune response is a prerequisite to mount a highly antigenspecific adaptive immune response consisting of T-cell differentiation into effector subsets and B-cell differentiation into antibody-secreting plasma cells. Commonly, allergy is characterized by dendritic cells presenting allergenic peptides, activated Th2 cells producing signature cytokines like IL-4 and IL-5, and B-cells producing allergen-specific IgE antibodies. Under non-allergic conditions tolerance mechanisms, comprising regulatory T-cell subsets, are suppressing potential immune responses to allergen exposure. The protein structure of many allergens has been resolved and has provided an explanation for the epitope-specific IgE cross-reactivity responsible for the pollen food syndrome. The knowledge on the protein characteristics of the major food allergens can provide better understanding why certain types of allergic symptoms can develop in particular individuals. Together with information on the genetic basis and the modulatory capacity of the environment, the Allergy Consortium Wageningen sets out to develop preventive measures to reduce allergic sensitization, to give advice to reduce allergen exposure and induce symptom reduction, and to provide clues to the management of an existing allergy.",
author = "P.V. Jeurink and H.F.J. Savelkoul",
year = "2005",
language = "English",
isbn = "9781402038969",
series = "Wageningen UR Frontis Series",
publisher = "Springer - Life Sciences",
number = "10",
pages = "13--27",
editor = "{Dr. Gilissen}, L.J.E.J. and {Prof.dr. Wichers}, H.J. and {Prof.dr.ir. Savelkoul}, H.F.J. and R.J. Bogers",
booktitle = "Allergy Matters : new approaches to allergy prevention and management",

}

Jeurink, PV & Savelkoul, HFJ 2005, Induction and regulation of allergen-specific IgE. in LJEJ Dr. Gilissen, HJ Prof.dr. Wichers, HFJ Prof.dr.ir. Savelkoul & RJ Bogers (eds), Allergy Matters : new approaches to allergy prevention and management. Wageningen UR Frontis Series, no. 10, pp. 13-27.

Induction and regulation of allergen-specific IgE. / Jeurink, P.V.; Savelkoul, H.F.J.

Allergy Matters : new approaches to allergy prevention and management. ed. / L.J.E.J. Dr. Gilissen; H.J. Prof.dr. Wichers; H.F.J. Prof.dr.ir. Savelkoul; R.J. Bogers. 2005. p. 13-27 (Wageningen UR Frontis Series; No. 10).

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Induction and regulation of allergen-specific IgE

AU - Jeurink, P.V.

AU - Savelkoul, H.F.J.

PY - 2005

Y1 - 2005

N2 - The immune response is characterized by an initial rapid activation of the innate defence system, geared at recognizing common structures shared by many microorganisms. This innate immune response is a prerequisite to mount a highly antigenspecific adaptive immune response consisting of T-cell differentiation into effector subsets and B-cell differentiation into antibody-secreting plasma cells. Commonly, allergy is characterized by dendritic cells presenting allergenic peptides, activated Th2 cells producing signature cytokines like IL-4 and IL-5, and B-cells producing allergen-specific IgE antibodies. Under non-allergic conditions tolerance mechanisms, comprising regulatory T-cell subsets, are suppressing potential immune responses to allergen exposure. The protein structure of many allergens has been resolved and has provided an explanation for the epitope-specific IgE cross-reactivity responsible for the pollen food syndrome. The knowledge on the protein characteristics of the major food allergens can provide better understanding why certain types of allergic symptoms can develop in particular individuals. Together with information on the genetic basis and the modulatory capacity of the environment, the Allergy Consortium Wageningen sets out to develop preventive measures to reduce allergic sensitization, to give advice to reduce allergen exposure and induce symptom reduction, and to provide clues to the management of an existing allergy.

AB - The immune response is characterized by an initial rapid activation of the innate defence system, geared at recognizing common structures shared by many microorganisms. This innate immune response is a prerequisite to mount a highly antigenspecific adaptive immune response consisting of T-cell differentiation into effector subsets and B-cell differentiation into antibody-secreting plasma cells. Commonly, allergy is characterized by dendritic cells presenting allergenic peptides, activated Th2 cells producing signature cytokines like IL-4 and IL-5, and B-cells producing allergen-specific IgE antibodies. Under non-allergic conditions tolerance mechanisms, comprising regulatory T-cell subsets, are suppressing potential immune responses to allergen exposure. The protein structure of many allergens has been resolved and has provided an explanation for the epitope-specific IgE cross-reactivity responsible for the pollen food syndrome. The knowledge on the protein characteristics of the major food allergens can provide better understanding why certain types of allergic symptoms can develop in particular individuals. Together with information on the genetic basis and the modulatory capacity of the environment, the Allergy Consortium Wageningen sets out to develop preventive measures to reduce allergic sensitization, to give advice to reduce allergen exposure and induce symptom reduction, and to provide clues to the management of an existing allergy.

M3 - Chapter

SN - 9781402038969

T3 - Wageningen UR Frontis Series

SP - 13

EP - 27

BT - Allergy Matters : new approaches to allergy prevention and management

A2 - Dr. Gilissen, L.J.E.J.

A2 - Prof.dr. Wichers, H.J.

A2 - Prof.dr.ir. Savelkoul, H.F.J.

A2 - Bogers, R.J.

ER -

Jeurink PV, Savelkoul HFJ. Induction and regulation of allergen-specific IgE. In Dr. Gilissen LJEJ, Prof.dr. Wichers HJ, Prof.dr.ir. Savelkoul HFJ, Bogers RJ, editors, Allergy Matters : new approaches to allergy prevention and management. 2005. p. 13-27. (Wageningen UR Frontis Series; 10).