Increasing quality of life in pulmonary arterial hypertension: is there a role for nutrition?

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Pulmonary arterial hypertension (PAH) is a progressive disease primarily affecting the pulmonary vasculature and heart. PAH patients suffer from exercise intolerance and fatigue, negatively affecting their quality of life. This review summarizes current insights in the pathophysiological mechanisms underlying PAH. It zooms in on the potential involvement of nutritional status and micronutrient deficiencies on PAH exercise intolerance and fatigue, also summarizing the potential benefits of exercise and nutritional interventions. Pubmed/Medline, Scopus, and Web of Science were searched for publications on pathophysiological mechanisms of PAH negatively affecting physical activity potential and nutritional status, and for potential effects of interventions involving exercise or nutritional measures known to improve exercise intolerance. Pathophysiological processes that contribute to exercise intolerance and impaired quality of life of PAH patients include right ventricular dysfunction, inflammation, skeletal muscle alterations, and dysfunctional energy metabolism. PAH-related nutritional deficiencies and metabolic alterations have been linked to fatigue, exercise intolerance, and endothelial dysfunction. Available evidence suggests that exercise interventions can be effective in PAH patients to improve exercise tolerance and decrease fatigue. By contrast, knowledge on the prevalence of micronutrient deficiencies and the possible effects of nutritional interventions in PAH patients is limited. Although data on nutritional status and micronutrient deficiencies in PAH are scarce, the available knowledge, including that from adjacent fields, suggests that nutritional intervention to correct deficiencies and metabolic alterations may contribute to a reduction of disease burden.

Original languageEnglish
Pages (from-to)711–722
JournalHeart Failure Reviews
Volume23
Issue number5
Early online date16 Jun 2018
DOIs
Publication statusPublished - Aug 2018

Fingerprint

Pulmonary Hypertension
Quality of Life
Exercise
Fatigue
Micronutrients
Nutritional Status
Right Ventricular Dysfunction
Exercise Tolerance
Patient Rights
PubMed
Malnutrition
Energy Metabolism
Publications
Skeletal Muscle
Inflammation
Lung

Keywords

  • Deficiencies
  • Exercise
  • Lifestyle
  • Nutrition
  • Pulmonary arterial hypertension
  • Review

Cite this

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title = "Increasing quality of life in pulmonary arterial hypertension: is there a role for nutrition?",
abstract = "Pulmonary arterial hypertension (PAH) is a progressive disease primarily affecting the pulmonary vasculature and heart. PAH patients suffer from exercise intolerance and fatigue, negatively affecting their quality of life. This review summarizes current insights in the pathophysiological mechanisms underlying PAH. It zooms in on the potential involvement of nutritional status and micronutrient deficiencies on PAH exercise intolerance and fatigue, also summarizing the potential benefits of exercise and nutritional interventions. Pubmed/Medline, Scopus, and Web of Science were searched for publications on pathophysiological mechanisms of PAH negatively affecting physical activity potential and nutritional status, and for potential effects of interventions involving exercise or nutritional measures known to improve exercise intolerance. Pathophysiological processes that contribute to exercise intolerance and impaired quality of life of PAH patients include right ventricular dysfunction, inflammation, skeletal muscle alterations, and dysfunctional energy metabolism. PAH-related nutritional deficiencies and metabolic alterations have been linked to fatigue, exercise intolerance, and endothelial dysfunction. Available evidence suggests that exercise interventions can be effective in PAH patients to improve exercise tolerance and decrease fatigue. By contrast, knowledge on the prevalence of micronutrient deficiencies and the possible effects of nutritional interventions in PAH patients is limited. Although data on nutritional status and micronutrient deficiencies in PAH are scarce, the available knowledge, including that from adjacent fields, suggests that nutritional intervention to correct deficiencies and metabolic alterations may contribute to a reduction of disease burden.",
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Increasing quality of life in pulmonary arterial hypertension : is there a role for nutrition? / Vinke, Paulien; Jansen, Suzanne M.; Witkamp, Renger F.; van Norren, Klaske.

In: Heart Failure Reviews, Vol. 23, No. 5, 08.2018, p. 711–722.

Research output: Contribution to journalArticleAcademicpeer-review

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