Increasing genetic gain by selecting for higher Mendelian sampling variance

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademicpeer-review

Abstract

Because of linkage and variation in heterozygosity, individuals differ in the Mendelian sampling variance on their gametes. Thus some parents produce genetically more variable offspring than others. With genomic EBV and phased genotypes, these differences can be quantified and potentially used to increase genetic gain. Here we show that genetic gain and the probability of breeding a top-ranking individual can be increased by selecting individuals on an index of their GEBV and the standard deviation on the GEBV of their gametes (SDGEBV). The optimum index was , where is the standardized truncation point belonging to the selected proportion p. Compared to selection on ordinary GEBV, in dairy cattle the probability of breeding a top-ranking individual can be increased by 36%, and response to selection by 3.6% when selection is strong (p = 0.001). Preselection on GEBV facilitates implementation with little loss of gain.
Original languageEnglish
Title of host publicationProceedings of the 11th World Congress on Genetics Applied to Livestock Production
Subtitle of host publicationVolume Genetic Gain - Breeding Strategies 2
PublisherWCGALP
Number of pages5
Publication statusPublished - 1 Feb 2018
EventWorld Congress on Genetics Applied to Livestock Production - Auckland, New Zealand
Duration: 11 Feb 201816 Feb 2018

Conference

ConferenceWorld Congress on Genetics Applied to Livestock Production
Abbreviated titleWCGALP 2018
CountryNew Zealand
CityAuckland
Period11/02/1816/02/18

Fingerprint

genetic improvement
germ cells
breeding
dairy cattle
linkage (genetics)
heterozygosity
genomics
sampling
genotype

Cite this

Bijma, P., Wientjes, Y. C. J., & Calus, M. P. L. (2018). Increasing genetic gain by selecting for higher Mendelian sampling variance. In Proceedings of the 11th World Congress on Genetics Applied to Livestock Production: Volume Genetic Gain - Breeding Strategies 2 [47] WCGALP.
Bijma, P. ; Wientjes, Y.C.J. ; Calus, M.P.L. / Increasing genetic gain by selecting for higher Mendelian sampling variance. Proceedings of the 11th World Congress on Genetics Applied to Livestock Production: Volume Genetic Gain - Breeding Strategies 2. WCGALP, 2018.
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Bijma, P, Wientjes, YCJ & Calus, MPL 2018, Increasing genetic gain by selecting for higher Mendelian sampling variance. in Proceedings of the 11th World Congress on Genetics Applied to Livestock Production: Volume Genetic Gain - Breeding Strategies 2., 47, WCGALP, World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand, 11/02/18.

Increasing genetic gain by selecting for higher Mendelian sampling variance. / Bijma, P.; Wientjes, Y.C.J.; Calus, M.P.L.

Proceedings of the 11th World Congress on Genetics Applied to Livestock Production: Volume Genetic Gain - Breeding Strategies 2. WCGALP, 2018. 47.

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademicpeer-review

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N2 - Because of linkage and variation in heterozygosity, individuals differ in the Mendelian sampling variance on their gametes. Thus some parents produce genetically more variable offspring than others. With genomic EBV and phased genotypes, these differences can be quantified and potentially used to increase genetic gain. Here we show that genetic gain and the probability of breeding a top-ranking individual can be increased by selecting individuals on an index of their GEBV and the standard deviation on the GEBV of their gametes (SDGEBV). The optimum index was , where is the standardized truncation point belonging to the selected proportion p. Compared to selection on ordinary GEBV, in dairy cattle the probability of breeding a top-ranking individual can be increased by 36%, and response to selection by 3.6% when selection is strong (p = 0.001). Preselection on GEBV facilitates implementation with little loss of gain.

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Bijma P, Wientjes YCJ, Calus MPL. Increasing genetic gain by selecting for higher Mendelian sampling variance. In Proceedings of the 11th World Congress on Genetics Applied to Livestock Production: Volume Genetic Gain - Breeding Strategies 2. WCGALP. 2018. 47