Increasing genetic gain by selecting for higher Mendelian sampling variance

P. Bijma; Y.C.J. Wientjes; M.P.L. Calus

Increasing genetic gain by selecting for higher Mendelian sampling variance

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic › peer-review

Abstract

Because of linkage and variation in heterozygosity, individuals differ in the Mendelian sampling variance on their gametes. Thus some parents produce genetically more variable offspring than others. With genomic EBV and phased genotypes, these differences can be quantified and potentially used to increase genetic gain. Here we show that genetic gain and the probability of breeding a top-ranking individual can be increased by selecting individuals on an index of their GEBV and the standard deviation on the GEBV of their gametes (SDGEBV). The optimum index was , where is the standardized truncation point belonging to the selected proportion p. Compared to selection on ordinary GEBV, in dairy cattle the probability of breeding a top-ranking individual can be increased by 36%, and response to selection by 3.6% when selection is strong (p = 0.001). Preselection on GEBV facilitates implementation with little loss of gain.

Original language	English
Title of host publication	Proceedings of the 11th World Congress on Genetics Applied to Livestock Production
Subtitle of host publication	Volume Genetic Gain - Breeding Strategies 2
Publisher	WCGALP
Number of pages	5
Publication status	Published - 1 Feb 2018
Event	World Congress on Genetics Applied to Livestock Production (2018) - Auckland, New Zealand Duration: 11 Feb 2018 → 16 Feb 2018

Conference

Conference	World Congress on Genetics Applied to Livestock Production (2018)
Abbreviated title	WCGALP 2018
Country/Territory	New Zealand
City	Auckland
Period	11/02/18 → 16/02/18

Access to Document

http://www.wcgalp.org/proceedings/2018/increasing-genetic-gain-selecting-higher-mendelian-sampling-varianceLicence: CC BY-NC-ND

1 Finished
1 Active

Breed4Food (WUR)
1/01/13 → …
Project: Other
AF-16022 Breed4Food II (BO-63-001-009, BO-47-001-021, BO-22.04-025-001, BO-22.04-011-001, BO-22.02-011-001)
Veerkamp, R.
1/01/14 → 31/12/21
Project: EZproject

Cite this

Bijma, P., Wientjes, Y. C. J., & Calus, M. P. L. (2018). Increasing genetic gain by selecting for higher Mendelian sampling variance. In Proceedings of the 11th World Congress on Genetics Applied to Livestock Production: Volume Genetic Gain - Breeding Strategies 2 [47] WCGALP. http://www.wcgalp.org/proceedings/2018/increasing-genetic-gain-selecting-higher-mendelian-sampling-variance

@inproceedings{fc53aa388f9148f99a904633bff73b19,

title = "Increasing genetic gain by selecting for higher Mendelian sampling variance",

abstract = "Because of linkage and variation in heterozygosity, individuals differ in the Mendelian sampling variance on their gametes. Thus some parents produce genetically more variable offspring than others. With genomic EBV and phased genotypes, these differences can be quantified and potentially used to increase genetic gain. Here we show that genetic gain and the probability of breeding a top-ranking individual can be increased by selecting individuals on an index of their GEBV and the standard deviation on the GEBV of their gametes (SDGEBV). The optimum index was , where is the standardized truncation point belonging to the selected proportion p. Compared to selection on ordinary GEBV, in dairy cattle the probability of breeding a top-ranking individual can be increased by 36%, and response to selection by 3.6% when selection is strong (p = 0.001). Preselection on GEBV facilitates implementation with little loss of gain. ",

author = "P. Bijma and Y.C.J. Wientjes and M.P.L. Calus",

year = "2018",

month = feb,

day = "1",

language = "English",

booktitle = "Proceedings of the 11th World Congress on Genetics Applied to Livestock Production",

publisher = "WCGALP",

note = "World Congress on Genetics Applied to Livestock Production (2018), WCGALP 2018 ; Conference date: 11-02-2018 Through 16-02-2018",

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Bijma, P , Wientjes, YCJ & Calus, MPL 2018, Increasing genetic gain by selecting for higher Mendelian sampling variance. in Proceedings of the 11th World Congress on Genetics Applied to Livestock Production: Volume Genetic Gain - Breeding Strategies 2., 47, WCGALP, World Congress on Genetics Applied to Livestock Production (2018), Auckland, New Zealand, 11/02/18. <http://www.wcgalp.org/proceedings/2018/increasing-genetic-gain-selecting-higher-mendelian-sampling-variance>

Increasing genetic gain by selecting for higher Mendelian sampling variance. / Bijma, P.; Wientjes, Y.C.J.; Calus, M.P.L.

Proceedings of the 11th World Congress on Genetics Applied to Livestock Production: Volume Genetic Gain - Breeding Strategies 2. WCGALP, 2018. 47.

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic › peer-review

TY - GEN

T1 - Increasing genetic gain by selecting for higher Mendelian sampling variance

AU - Bijma, P.

AU - Wientjes, Y.C.J.

AU - Calus, M.P.L.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Because of linkage and variation in heterozygosity, individuals differ in the Mendelian sampling variance on their gametes. Thus some parents produce genetically more variable offspring than others. With genomic EBV and phased genotypes, these differences can be quantified and potentially used to increase genetic gain. Here we show that genetic gain and the probability of breeding a top-ranking individual can be increased by selecting individuals on an index of their GEBV and the standard deviation on the GEBV of their gametes (SDGEBV). The optimum index was , where is the standardized truncation point belonging to the selected proportion p. Compared to selection on ordinary GEBV, in dairy cattle the probability of breeding a top-ranking individual can be increased by 36%, and response to selection by 3.6% when selection is strong (p = 0.001). Preselection on GEBV facilitates implementation with little loss of gain.

AB - Because of linkage and variation in heterozygosity, individuals differ in the Mendelian sampling variance on their gametes. Thus some parents produce genetically more variable offspring than others. With genomic EBV and phased genotypes, these differences can be quantified and potentially used to increase genetic gain. Here we show that genetic gain and the probability of breeding a top-ranking individual can be increased by selecting individuals on an index of their GEBV and the standard deviation on the GEBV of their gametes (SDGEBV). The optimum index was , where is the standardized truncation point belonging to the selected proportion p. Compared to selection on ordinary GEBV, in dairy cattle the probability of breeding a top-ranking individual can be increased by 36%, and response to selection by 3.6% when selection is strong (p = 0.001). Preselection on GEBV facilitates implementation with little loss of gain.

M3 - Conference paper

BT - Proceedings of the 11th World Congress on Genetics Applied to Livestock Production

PB - WCGALP

T2 - World Congress on Genetics Applied to Livestock Production (2018)

Y2 - 11 February 2018 through 16 February 2018

ER -

Increasing genetic gain by selecting for higher Mendelian sampling variance

Abstract

Conference

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Projects

Breed4Food (WUR)

AF-16022 Breed4Food II (BO-63-001-009, BO-47-001-021, BO-22.04-025-001, BO-22.04-011-001, BO-22.02-011-001)

Cite this