Increased risk for Campylobacter jejuni and C. coli infection of pet origin in dog owners and evidence for genetic association between strains causing infection in humans and their pets

L.M. Gras, J.H. Smid, J.A. Wagenaar, M.G.J. Koene, A.H. Havelaar, I.H.M. Friesema, N.P. French, C. Flemming, J.D. Galson, C. Graziani, L. Busani, W. van Pelt

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Abstract

We compared Campylobacter jejuni/coli multilocus sequence types (STs) from pets (dogs/cats) and their owners and investigated risk factors for pet-associated human campylobacteriosis using a combined source-attribution and case-control analysis. In total, 132/687 pet stools were Campylobacter-positive, resulting in 499 strains isolated (320 C. upsaliensis/helveticus, 100 C. jejuni, 33 C. hyointestinalis/fetus, 10 C. lari, 4 C. coli, 32 unidentified). There were 737 human and 104 pet C. jejuni/coli strains assigned to 154 and 49 STs, respectively. Dog, particularly puppy, owners were at increased risk of infection with pet-associated STs. In 2/68 cases vs. 0·134/68 expected by chance, a pet and its owner were infected with an identical ST (ST45, ST658). Although common sources of infection and directionality of transmission between pets and humans were unknown, dog ownership significantly increased the risk for pet-associated human C. jejuni/coli infection and isolation of identical strains in humans and their pets occurred significantly more often than expected.
Original languageEnglish
Pages (from-to)2526-2535
JournalEpidemiology and Infection
Volume141
Issue number12
DOIs
Publication statusPublished - 2013

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Campylobacter jejuni
Pets
Dogs
Infection
Campylobacter coli
Infectious Disease Transmission
Campylobacter
Ownership
Cats
Fetus

Keywords

  • fragment length polymorphism
  • cats
  • netherlands
  • identification
  • spp.
  • switzerland
  • scotland

Cite this

Gras, L.M. ; Smid, J.H. ; Wagenaar, J.A. ; Koene, M.G.J. ; Havelaar, A.H. ; Friesema, I.H.M. ; French, N.P. ; Flemming, C. ; Galson, J.D. ; Graziani, C. ; Busani, L. ; van Pelt, W. / Increased risk for Campylobacter jejuni and C. coli infection of pet origin in dog owners and evidence for genetic association between strains causing infection in humans and their pets. In: Epidemiology and Infection. 2013 ; Vol. 141, No. 12. pp. 2526-2535.
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abstract = "We compared Campylobacter jejuni/coli multilocus sequence types (STs) from pets (dogs/cats) and their owners and investigated risk factors for pet-associated human campylobacteriosis using a combined source-attribution and case-control analysis. In total, 132/687 pet stools were Campylobacter-positive, resulting in 499 strains isolated (320 C. upsaliensis/helveticus, 100 C. jejuni, 33 C. hyointestinalis/fetus, 10 C. lari, 4 C. coli, 32 unidentified). There were 737 human and 104 pet C. jejuni/coli strains assigned to 154 and 49 STs, respectively. Dog, particularly puppy, owners were at increased risk of infection with pet-associated STs. In 2/68 cases vs. 0·134/68 expected by chance, a pet and its owner were infected with an identical ST (ST45, ST658). Although common sources of infection and directionality of transmission between pets and humans were unknown, dog ownership significantly increased the risk for pet-associated human C. jejuni/coli infection and isolation of identical strains in humans and their pets occurred significantly more often than expected.",
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author = "L.M. Gras and J.H. Smid and J.A. Wagenaar and M.G.J. Koene and A.H. Havelaar and I.H.M. Friesema and N.P. French and C. Flemming and J.D. Galson and C. Graziani and L. Busani and {van Pelt}, W.",
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language = "English",
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Gras, LM, Smid, JH, Wagenaar, JA, Koene, MGJ, Havelaar, AH, Friesema, IHM, French, NP, Flemming, C, Galson, JD, Graziani, C, Busani, L & van Pelt, W 2013, 'Increased risk for Campylobacter jejuni and C. coli infection of pet origin in dog owners and evidence for genetic association between strains causing infection in humans and their pets', Epidemiology and Infection, vol. 141, no. 12, pp. 2526-2535. https://doi.org/10.1017/S0950268813000356

Increased risk for Campylobacter jejuni and C. coli infection of pet origin in dog owners and evidence for genetic association between strains causing infection in humans and their pets. / Gras, L.M.; Smid, J.H.; Wagenaar, J.A.; Koene, M.G.J.; Havelaar, A.H.; Friesema, I.H.M.; French, N.P.; Flemming, C.; Galson, J.D.; Graziani, C.; Busani, L.; van Pelt, W.

In: Epidemiology and Infection, Vol. 141, No. 12, 2013, p. 2526-2535.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Increased risk for Campylobacter jejuni and C. coli infection of pet origin in dog owners and evidence for genetic association between strains causing infection in humans and their pets

AU - Gras, L.M.

AU - Smid, J.H.

AU - Wagenaar, J.A.

AU - Koene, M.G.J.

AU - Havelaar, A.H.

AU - Friesema, I.H.M.

AU - French, N.P.

AU - Flemming, C.

AU - Galson, J.D.

AU - Graziani, C.

AU - Busani, L.

AU - van Pelt, W.

PY - 2013

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N2 - We compared Campylobacter jejuni/coli multilocus sequence types (STs) from pets (dogs/cats) and their owners and investigated risk factors for pet-associated human campylobacteriosis using a combined source-attribution and case-control analysis. In total, 132/687 pet stools were Campylobacter-positive, resulting in 499 strains isolated (320 C. upsaliensis/helveticus, 100 C. jejuni, 33 C. hyointestinalis/fetus, 10 C. lari, 4 C. coli, 32 unidentified). There were 737 human and 104 pet C. jejuni/coli strains assigned to 154 and 49 STs, respectively. Dog, particularly puppy, owners were at increased risk of infection with pet-associated STs. In 2/68 cases vs. 0·134/68 expected by chance, a pet and its owner were infected with an identical ST (ST45, ST658). Although common sources of infection and directionality of transmission between pets and humans were unknown, dog ownership significantly increased the risk for pet-associated human C. jejuni/coli infection and isolation of identical strains in humans and their pets occurred significantly more often than expected.

AB - We compared Campylobacter jejuni/coli multilocus sequence types (STs) from pets (dogs/cats) and their owners and investigated risk factors for pet-associated human campylobacteriosis using a combined source-attribution and case-control analysis. In total, 132/687 pet stools were Campylobacter-positive, resulting in 499 strains isolated (320 C. upsaliensis/helveticus, 100 C. jejuni, 33 C. hyointestinalis/fetus, 10 C. lari, 4 C. coli, 32 unidentified). There were 737 human and 104 pet C. jejuni/coli strains assigned to 154 and 49 STs, respectively. Dog, particularly puppy, owners were at increased risk of infection with pet-associated STs. In 2/68 cases vs. 0·134/68 expected by chance, a pet and its owner were infected with an identical ST (ST45, ST658). Although common sources of infection and directionality of transmission between pets and humans were unknown, dog ownership significantly increased the risk for pet-associated human C. jejuni/coli infection and isolation of identical strains in humans and their pets occurred significantly more often than expected.

KW - fragment length polymorphism

KW - cats

KW - netherlands

KW - identification

KW - spp.

KW - switzerland

KW - scotland

U2 - 10.1017/S0950268813000356

DO - 10.1017/S0950268813000356

M3 - Article

VL - 141

SP - 2526

EP - 2535

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 12

ER -