Increased prevalence of restless legs syndrome in patients with Crohn’s disease

Patrick D. Hoek, Marcel G. Smits, N.M. de Roos, Roselyne M. Rijsman, B.J.M. Witteman

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

OBJECTIVE:
To determine (a) the incidence of restless legs syndrome (RLS) in patients with Crohn's disease (CD), (b) whether and how the occurrence and severity of RLS is related to severity of CD, and (c) how RLS influences the quality of life of CD patients.
BASIC METHODS:
We carried out a cross-sectional questionnaire study in a random selection of 144 CD patients and 80 controls. Differences were calculated using a χ-test (categorical data), an independent T-test (continuous data, normal distribution), or a Mann-Whitney U-test (continuous data, non-normal distribution). Logistic regression analysis was carried out to establish the relation between CD and RLS after adjusting for risk factors.
MAIN RESULTS:
The prevalence of RLS was 25.7% (37/144) in CD patients compared with 12.5% (10/80) in the control group (P=0.02). CD patients using caffeine and patients with arthralgias had a higher risk for RLS. A higher score on the modified Harvey Bradshaw Index and CD-related surgery were also associated with a higher risk for RLS. CD-related surgery was also associated with a more severe course of RLS. Patients and controls with RLS had a lower score on 'physical functioning', one of the subcategories of the RAND-36 quality-of-life questionnaire.
PRINCIPAL CONCLUSION:
RLS occurs more frequently in patients with CD compared with healthy individuals. A more severe course of CD seems to be associated with a higher risk for RLS. The presence of RLS has a negative influence on quality of life, mainly interfering with physical activities of daily life
Original languageEnglish
Pages (from-to)951-955
JournalEuropean Journal of Gastroenterology & Hepatology
Volume27
Issue number8
DOIs
Publication statusPublished - 2015

Fingerprint

Restless Legs Syndrome
Crohn Disease
Quality of Life
Normal Distribution
Arthralgia
Nonparametric Statistics
Caffeine

Keywords

  • Crohn’s disease
  • quality of life
  • restless legs syndrome

Cite this

@article{c40f9f1d2f4045b1846910bc8be03570,
title = "Increased prevalence of restless legs syndrome in patients with Crohn’s disease",
abstract = "OBJECTIVE: To determine (a) the incidence of restless legs syndrome (RLS) in patients with Crohn's disease (CD), (b) whether and how the occurrence and severity of RLS is related to severity of CD, and (c) how RLS influences the quality of life of CD patients.BASIC METHODS: We carried out a cross-sectional questionnaire study in a random selection of 144 CD patients and 80 controls. Differences were calculated using a χ-test (categorical data), an independent T-test (continuous data, normal distribution), or a Mann-Whitney U-test (continuous data, non-normal distribution). Logistic regression analysis was carried out to establish the relation between CD and RLS after adjusting for risk factors.MAIN RESULTS: The prevalence of RLS was 25.7{\%} (37/144) in CD patients compared with 12.5{\%} (10/80) in the control group (P=0.02). CD patients using caffeine and patients with arthralgias had a higher risk for RLS. A higher score on the modified Harvey Bradshaw Index and CD-related surgery were also associated with a higher risk for RLS. CD-related surgery was also associated with a more severe course of RLS. Patients and controls with RLS had a lower score on 'physical functioning', one of the subcategories of the RAND-36 quality-of-life questionnaire.PRINCIPAL CONCLUSION: RLS occurs more frequently in patients with CD compared with healthy individuals. A more severe course of CD seems to be associated with a higher risk for RLS. The presence of RLS has a negative influence on quality of life, mainly interfering with physical activities of daily life",
keywords = "Crohn’s disease, quality of life, restless legs syndrome",
author = "Hoek, {Patrick D.} and Smits, {Marcel G.} and {de Roos}, N.M. and Rijsman, {Roselyne M.} and B.J.M. Witteman",
year = "2015",
doi = "10.1097/MEG.0000000000000386",
language = "English",
volume = "27",
pages = "951--955",
journal = "European Journal of Gastroenterology & Hepatology",
issn = "0954-691X",
publisher = "Lippincott, Williams & Wilkins",
number = "8",

}

Increased prevalence of restless legs syndrome in patients with Crohn’s disease. / Hoek, Patrick D.; Smits, Marcel G.; de Roos, N.M.; Rijsman, Roselyne M.; Witteman, B.J.M.

In: European Journal of Gastroenterology & Hepatology, Vol. 27, No. 8, 2015, p. 951-955.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Increased prevalence of restless legs syndrome in patients with Crohn’s disease

AU - Hoek, Patrick D.

AU - Smits, Marcel G.

AU - de Roos, N.M.

AU - Rijsman, Roselyne M.

AU - Witteman, B.J.M.

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: To determine (a) the incidence of restless legs syndrome (RLS) in patients with Crohn's disease (CD), (b) whether and how the occurrence and severity of RLS is related to severity of CD, and (c) how RLS influences the quality of life of CD patients.BASIC METHODS: We carried out a cross-sectional questionnaire study in a random selection of 144 CD patients and 80 controls. Differences were calculated using a χ-test (categorical data), an independent T-test (continuous data, normal distribution), or a Mann-Whitney U-test (continuous data, non-normal distribution). Logistic regression analysis was carried out to establish the relation between CD and RLS after adjusting for risk factors.MAIN RESULTS: The prevalence of RLS was 25.7% (37/144) in CD patients compared with 12.5% (10/80) in the control group (P=0.02). CD patients using caffeine and patients with arthralgias had a higher risk for RLS. A higher score on the modified Harvey Bradshaw Index and CD-related surgery were also associated with a higher risk for RLS. CD-related surgery was also associated with a more severe course of RLS. Patients and controls with RLS had a lower score on 'physical functioning', one of the subcategories of the RAND-36 quality-of-life questionnaire.PRINCIPAL CONCLUSION: RLS occurs more frequently in patients with CD compared with healthy individuals. A more severe course of CD seems to be associated with a higher risk for RLS. The presence of RLS has a negative influence on quality of life, mainly interfering with physical activities of daily life

AB - OBJECTIVE: To determine (a) the incidence of restless legs syndrome (RLS) in patients with Crohn's disease (CD), (b) whether and how the occurrence and severity of RLS is related to severity of CD, and (c) how RLS influences the quality of life of CD patients.BASIC METHODS: We carried out a cross-sectional questionnaire study in a random selection of 144 CD patients and 80 controls. Differences were calculated using a χ-test (categorical data), an independent T-test (continuous data, normal distribution), or a Mann-Whitney U-test (continuous data, non-normal distribution). Logistic regression analysis was carried out to establish the relation between CD and RLS after adjusting for risk factors.MAIN RESULTS: The prevalence of RLS was 25.7% (37/144) in CD patients compared with 12.5% (10/80) in the control group (P=0.02). CD patients using caffeine and patients with arthralgias had a higher risk for RLS. A higher score on the modified Harvey Bradshaw Index and CD-related surgery were also associated with a higher risk for RLS. CD-related surgery was also associated with a more severe course of RLS. Patients and controls with RLS had a lower score on 'physical functioning', one of the subcategories of the RAND-36 quality-of-life questionnaire.PRINCIPAL CONCLUSION: RLS occurs more frequently in patients with CD compared with healthy individuals. A more severe course of CD seems to be associated with a higher risk for RLS. The presence of RLS has a negative influence on quality of life, mainly interfering with physical activities of daily life

KW - Crohn’s disease

KW - quality of life

KW - restless legs syndrome

U2 - 10.1097/MEG.0000000000000386

DO - 10.1097/MEG.0000000000000386

M3 - Article

VL - 27

SP - 951

EP - 955

JO - European Journal of Gastroenterology & Hepatology

JF - European Journal of Gastroenterology & Hepatology

SN - 0954-691X

IS - 8

ER -