Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology

F. Hammiche, M. Vujkovic, W. Wijburg, J.H.M. de Vries, N.S. Macklon, J.S.E. Laven, R.P.M. Steegers-Theunissen

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91 Citations (Scopus)


The association between preconception dietary intake of the polyunsaturated fatty acids (LC-PUFAs) omega-6 and omega-3 and the E2 levels and IVF/intracytoplasmic sperm injection (ICSI) outcome were investigated in women in a prospective study. It revealed that high intakes of omega-3 LC-PUFA alpha-linolenic acid increase baseline E2, high intakes of eicosapentaenoic acid and docosahexaenoic acid reduce E2 response and the number of follicles after ovarian stimulation, and total omega-3 intake, in particular alpha-linolenic acid and docosahexaenoic acid, improve embryo morphology
Original languageEnglish
Pages (from-to)1820-1823
JournalFertility and Sterility
Issue number5
Publication statusPublished - 2011


  • in-vitro fertilization
  • ovarian stimulation
  • hormone-levels
  • holstein cows
  • energy-intake
  • dietary-fat
  • dairy-cows
  • fish-meal
  • women
  • supplementation


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