Inactivation of the BSE agent by the heat and pressure process for manufacturing gelatine

A.H. Grobben, P.J. Steele, R.A. Somerville, D. Taylor, B.E.C. Schreuder

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    14 Citations (Scopus)


    Dietary exposure to the bovine spongiform encephalopathy (BSE) agent is the probable cause of variant Creutzfeldt-Jakob disease in people. The industrial manufacturing process for the production of gelatine and colloidal protein by the heat and pressure process was downscaled accurately and its capacity to remove or inactivate BSE infectivity was investigated. Gelatine was made from bones experimentally contaminated with mouse brain infected with the 301V strain of mouse-passaged BSE agent in which the infective titre was 108·7 ID50/g. No infectivity was detected in the extracted protein (100·45 ID50/g), and the calculated clearance factor was 106·5 ID50 or more.
    Original languageEnglish
    Pages (from-to)277-281
    JournalVeterinary Record
    Issue number10
    Publication statusPublished - 2005


    • bovine-spongiform-encephalopathy
    • creutzfeldt-jakob-disease
    • scrapie agent
    • rendering procedures
    • theoretical implications
    • person transmission
    • strains
    • mice
    • resistance
    • virus


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