In vitro relative potencies of perfluoroalkyl substances (PFASs) based on gene expression changes in human HepaRG liver cells

J. Louisse; Styliani S. Fragki; D.E.M.C. Rijkers; A.W.F. Janssen; M. Staats; M.J. Zeilmaker; A.H. Piersma; Mirjam Luijten; L.A.P. Hoogenboom; A.A.C.M. Peijnenburg

In vitro relative potencies of perfluoroalkyl substances (PFASs) based on gene expression changes in human HepaRG liver cells

J. Louisse, Styliani S. Fragki, D.E.M.C. Rijkers, A.W.F. Janssen, M. Staats, M.J. Zeilmaker, A.H. Piersma, Mirjam Luijten, L.A.P. Hoogenboom, A.A.C.M. Peijnenburg

Research output: Contribution to conference › Poster › Academic

Abstract

Aims of the study:
To obtain insight into the cellular effects of PFASs on the human liver by
studying concentration-dependent whole genome gene expression
changes in PFOS-exposed HepaRG cells.
• To determine in vitro relative potencies of a series of PFASs (Figure 1)
based on concentration-dependent changes in expression of selected
genes in PFAS-exposed HepaRG cells.

Original language	English
Number of pages	1
Publication status	Published - 24 May 2022
Event	2022 annual meeting of the Netherlands Society of Toxicology: Green deal, Toxicology matter(s) - Hotel en congrescentrum de Reehorst, Wageningen, Netherlands Duration: 24 May 2022 → 25 May 2022 https://meeting2022.toxicologie.nl/

Conference

Conference	2022 annual meeting of the Netherlands Society of Toxicology
Country/Territory	Netherlands
City	Wageningen
Period	24/05/22 → 25/05/22
Internet address	https://meeting2022.toxicologie.nl/

Access to Document

https://edepot.wur.nl/571698

Speerpunt 1 - Opkomende risico's (KB-37-002-036)
Beekmann, K.
1/01/22 → 31/12/23
Project: EZproject

Cite this

Louisse, J., Fragki, S. S., Rijkers, D. E. M. C., Janssen, A. W. F., Staats, M., Zeilmaker, M. J., Piersma, A. H., Luijten, M., Hoogenboom, L. A. P., & Peijnenburg, A. A. C. M. (2022). In vitro relative potencies of perfluoroalkyl substances (PFASs) based on gene expression changes in human HepaRG liver cells. Poster session presented at 2022 annual meeting of the Netherlands Society of Toxicology, Wageningen, Netherlands. https://edepot.wur.nl/571698

@conference{67d870d90bf9495ba1a1ca228b162c21,

title = "In vitro relative potencies of perfluoroalkyl substances (PFASs) based on gene expression changes in human HepaRG liver cells",

abstract = "Aims of the study:To obtain insight into the cellular effects of PFASs on the human liver by studying concentration-dependent whole genome gene expression changes in PFOS-exposed HepaRG cells.• To determine in vitro relative potencies of a series of PFASs (Figure 1) based on concentration-dependent changes in expression of selected genes in PFAS-exposed HepaRG cells.",

author = "J. Louisse and Fragki, {Styliani S.} and D.E.M.C. Rijkers and A.W.F. Janssen and M. Staats and M.J. Zeilmaker and A.H. Piersma and Mirjam Luijten and L.A.P. Hoogenboom and A.A.C.M. Peijnenburg",

year = "2022",

month = may,

day = "24",

language = "English",

note = "2022 annual meeting of the Netherlands Society of Toxicology : Green deal, Toxicology matter(s) ; Conference date: 24-05-2022 Through 25-05-2022",

url = "https://meeting2022.toxicologie.nl/",

}

Louisse, J, Fragki, SS, Rijkers, DEMC , Janssen, AWF, Staats, M, Zeilmaker, MJ, Piersma, AH, Luijten, M, Hoogenboom, LAP & Peijnenburg, AACM 2022, 'In vitro relative potencies of perfluoroalkyl substances (PFASs) based on gene expression changes in human HepaRG liver cells', 2022 annual meeting of the Netherlands Society of Toxicology, Wageningen, Netherlands, 24/05/22 - 25/05/22. <https://edepot.wur.nl/571698>

In vitro relative potencies of perfluoroalkyl substances (PFASs) based on gene expression changes in human HepaRG liver cells. / Louisse, J.; Fragki, Styliani S.; Rijkers, D.E.M.C. et al.
2022. Poster session presented at 2022 annual meeting of the Netherlands Society of Toxicology, Wageningen, Netherlands.

Research output: Contribution to conference › Poster › Academic

TY - CONF

T1 - In vitro relative potencies of perfluoroalkyl substances (PFASs) based on gene expression changes in human HepaRG liver cells

AU - Louisse, J.

AU - Fragki, Styliani S.

AU - Rijkers, D.E.M.C.

AU - Janssen, A.W.F.

AU - Staats, M.

AU - Zeilmaker, M.J.

AU - Piersma, A.H.

AU - Luijten, Mirjam

AU - Hoogenboom, L.A.P.

AU - Peijnenburg, A.A.C.M.

PY - 2022/5/24

Y1 - 2022/5/24

N2 - Aims of the study:To obtain insight into the cellular effects of PFASs on the human liver by studying concentration-dependent whole genome gene expression changes in PFOS-exposed HepaRG cells.• To determine in vitro relative potencies of a series of PFASs (Figure 1) based on concentration-dependent changes in expression of selected genes in PFAS-exposed HepaRG cells.

AB - Aims of the study:To obtain insight into the cellular effects of PFASs on the human liver by studying concentration-dependent whole genome gene expression changes in PFOS-exposed HepaRG cells.• To determine in vitro relative potencies of a series of PFASs (Figure 1) based on concentration-dependent changes in expression of selected genes in PFAS-exposed HepaRG cells.

M3 - Poster

T2 - 2022 annual meeting of the Netherlands Society of Toxicology

Y2 - 24 May 2022 through 25 May 2022

ER -

In vitro relative potencies of perfluoroalkyl substances (PFASs) based on gene expression changes in human HepaRG liver cells

Abstract

Conference

Access to Document

Fingerprint

Projects

Speerpunt 1 - Opkomende risico's (KB-37-002-036)

Cite this