In vitro relative potencies of perfluoroalkyl substances (PFASs) based on gene expression changes in human HepaRG liver cells

J. Louisse, Styliani S. Fragki, D.E.M.C. Rijkers, A.W.F. Janssen, M. Staats, M.J. Zeilmaker, A.H. Piersma, Mirjam Luijten, L.A.P. Hoogenboom, A.A.C.M. Peijnenburg

Research output: Contribution to conferencePoster

Abstract

Aims of the study:
To obtain insight into the cellular effects of PFASs on the human liver by
studying concentration-dependent whole genome gene expression
changes in PFOS-exposed HepaRG cells.
• To determine in vitro relative potencies of a series of PFASs (Figure 1)
based on concentration-dependent changes in expression of selected
genes in PFAS-exposed HepaRG cells.
Original languageEnglish
Number of pages1
Publication statusPublished - 24 May 2022
Event2022 annual meeting of the Netherlands Society of Toxicology: Green deal, Toxicology matter(s) - Hotel en congrescentrum de Reehorst, Wageningen, Netherlands
Duration: 24 May 202225 May 2022
https://meeting2022.toxicologie.nl/

Conference

Conference2022 annual meeting of the Netherlands Society of Toxicology
Country/TerritoryNetherlands
CityWageningen
Period24/05/2225/05/22
Internet address

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