In vitro method for determining cholestatic properties of a compound

A.A.C.M. Peijnenburg (Inventor), E. Szalowska (Inventor)

Research output: PatentOther research output

Abstract

The invention is in the field of medical diagnostics and molecular biology. It provides markers that may be used in an in vitro method for determining whether a compound has cholestatic properties. More in particular, the invention relates to an in vitro method for determining whether a compound has cholestatic properties, comprising the step of exposing a liver cell to the compound, incubating the liver cell with the compound for an appropriate amount of time, determining the expression level of genes Bcl2l11, Parp 16, Mras, Myo1e, Nme6 ABCG5, ABCG8, SERPINE1, BAAT, and KLF15 in the liver cell, wherein an aberrant expression of more than 4 of these genes indicates that the compound has cholestatic properties.
Original languageEnglish
Patent numberEP2762573
Priority date5/02/14
Publication statusPublished - 6 Aug 2014

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