In vitro evaluation of gastro-intestinal digestion and colonic biotransformation of curcuminoids considering different formulations and food matrices

Valentina Azzurra Papillo, Marco Arlorio, Monica Locatelli, Laura Fuso, Nicoletta Pellegrini, Vincenzo Fogliano

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Pharmaceutical formulations for improving stability and bioavailability of curcuminoids are often produced using excipients unsuitable for food applications. In this work, turmeric oleoresin was microencapsulated by spray drying using gum arabic and maltodextrins to prepare a new ingredient (GA/MD) for food industry. In vitro bioaccessibility and degradation of curcuminoids along the gastro-intestinal tract was investigated, and compared with two commercial ingredients, turmeric powder and Meriva®. Curcuminoids were significantly degraded under the gastro-intestinal conditions in all the formulations; however, their bioaccessibility in GA/MD ingredient was 25-fold higher than that of turmeric powder, but slightly lower (1.2-fold) to that of Meriva®. After addition to rice and yoghurt, the curcuminoid bioaccessibility of GA/MD was about 2- fold higher than for the ingredient alone and 1.5- fold higher than for Meriva®; furthermore, addition to rice improved bioaccessibility more than in yogurt. Studies using different coating agents and other food matrices are needed.

LanguageEnglish
Pages156-163
Number of pages8
JournalJournal of Functional Foods
Volume59
DOIs
Publication statusPublished - 1 Aug 2019

Fingerprint

Curcuma
food matrix
Biotransformation
biotransformation
turmeric
Digestion
Yogurt
ingredients
digestion
Food
Powders
yogurt
Gum Arabic
powders
Drug Compounding
Excipients
Food Industry
drug formulations
rice
oleoresins

Keywords

  • Bioaccessibility
  • Food matrix effect
  • Microencapsulation
  • Spray-drying
  • Turmeric
  • Twin-SHIME® dynamic model

Cite this

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abstract = "Pharmaceutical formulations for improving stability and bioavailability of curcuminoids are often produced using excipients unsuitable for food applications. In this work, turmeric oleoresin was microencapsulated by spray drying using gum arabic and maltodextrins to prepare a new ingredient (GA/MD) for food industry. In vitro bioaccessibility and degradation of curcuminoids along the gastro-intestinal tract was investigated, and compared with two commercial ingredients, turmeric powder and Meriva{\circledR}. Curcuminoids were significantly degraded under the gastro-intestinal conditions in all the formulations; however, their bioaccessibility in GA/MD ingredient was 25-fold higher than that of turmeric powder, but slightly lower (1.2-fold) to that of Meriva{\circledR}. After addition to rice and yoghurt, the curcuminoid bioaccessibility of GA/MD was about 2- fold higher than for the ingredient alone and 1.5- fold higher than for Meriva{\circledR}; furthermore, addition to rice improved bioaccessibility more than in yogurt. Studies using different coating agents and other food matrices are needed.",
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In vitro evaluation of gastro-intestinal digestion and colonic biotransformation of curcuminoids considering different formulations and food matrices. / Papillo, Valentina Azzurra; Arlorio, Marco; Locatelli, Monica; Fuso, Laura; Pellegrini, Nicoletta; Fogliano, Vincenzo.

In: Journal of Functional Foods, Vol. 59, 01.08.2019, p. 156-163.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Pellegrini, Nicoletta

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