Improvement of goat TSE discriminative diagnosis and susceptibility based assessment of BSE infectivity in goat milk and meat

A. Bossers, J.P.M. Langeveld

Research output: Book/ReportReportProfessional

Abstract

In light of the known ability of the BSE agent to cross the animal/human species barrier, the evidence establishing the presence of BSE in goat is especially alarming, as it represents a potential risk of food-born contamination to human consumers of goat milk and meat products. The main objective has been to determine the tissue distribution of BSE after oral exposure of goats while simultaneously generating in dispensable data on genetic susceptibility in the most commonly used production breeds. Our approach integrates the predicted influence of PrP gene polymorphisms on scrapie and BSE susceptibility so that it could potentially be used for the control of field TSE outbreaks in goats. This proposal aims: - at providing data to allow evaluation of human risk associated with BSE passaged in goat; - at providing pathogenesis data and biologic al material from first and second passage BSE in goats; - at evaluating the possibility of BSE self-maintenance in goats by maternal/horizontal transmission; - at validating and improving our ability to detect and discriminate caprine BSE from goat scrapie.
Original languageEnglish
Place of PublicationLelystad
PublisherCentral Veterinary Institute of Wageningen UR (CVI)
Number of pages102
Publication statusPublished - 2012

Keywords

  • goat keeping
  • goat diseases
  • bovine spongiform encephalopathy
  • zoonoses
  • disease transmission
  • scrapie
  • risk factors
  • goat milk
  • food safety
  • transmissible spongiform encephalopathy

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  • Cite this

    Bossers, A., & Langeveld, J. P. M. (2012). Improvement of goat TSE discriminative diagnosis and susceptibility based assessment of BSE infectivity in goat milk and meat. Lelystad: Central Veterinary Institute of Wageningen UR (CVI).