Improved CRISPR-Cpf1 genome editing tool

J. van der Oost; P. van Baarlen; Rogier Louwen

Improved CRISPR-Cpf1 genome editing tool

J. van der Oost (Inventor), P. van Baarlen (Inventor), Rogier Louwen (Inventor)

Research output: Patent › Other research output

Abstract

The invention relates to a Cpf1-based nuclease complex, wherein the guide RNA sequence is irreversibly crosslinked to the Cpf1 protein. The cross-link may be a covalent binding or a non-covalent binding. Such a complex may be used in delivering constructs to a cell that are capable of gene-editing. Use of this cross-linked complex will result in less off-targeting.

Original language	English
Patent number	WO2017155407
Priority date	11/03/16
Publication status	Published - 14 Sep 2017

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https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2017155407A1&KC=A1&FT=D&ND=3&date=20170914&DB=EPODOC&locale=en_EP

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title = "Improved CRISPR-Cpf1 genome editing tool ",

abstract = "The invention relates to a Cpf1-based nuclease complex, wherein the guide RNA sequence is irreversibly crosslinked to the Cpf1 protein. The cross-link may be a covalent binding or a non-covalent binding. Such a complex may be used in delivering constructs to a cell that are capable of gene-editing. Use of this cross-linked complex will result in less off-targeting.",

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AB - The invention relates to a Cpf1-based nuclease complex, wherein the guide RNA sequence is irreversibly crosslinked to the Cpf1 protein. The cross-link may be a covalent binding or a non-covalent binding. Such a complex may be used in delivering constructs to a cell that are capable of gene-editing. Use of this cross-linked complex will result in less off-targeting.

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