Implications of gut microbiota in complex human diseases

Dahai Yu*, Xin Meng, Willem M. de Vos, Hao Wu, Xuexun Fang, Amit K. Maiti*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)


Humans, throughout the life cycle, from birth to death, are accompanied by the presence of gut microbes. Environmental factors, lifestyle, age and other factors can affect the balance of intestinal microbiota and their impact on human health. A large amount of data show that dietary, prebiotics, antibiotics can regulate various diseases through gut microbes. In this review, we focus on the role of gut microbes in the development of metabolic, gastrointestinal, neurological, immune diseases and, cancer. We also discuss the interaction between gut microbes and the host with respect to their beneficial and harmful effects, including their metabolites, microbial enzymes, small molecules and inflammatory molecules. More specifically, we evaluate the potential ability of gut microbes to cure diseases through Fecal Microbial Transplantation (FMT), which is expected to become a new type of clinical strategy for the treatment of various diseases

Original languageEnglish
Article number12661
JournalInternational Journal of Molecular Sciences
Issue number23
Publication statusPublished - 30 Nov 2021


  • Bacteria
  • Disease
  • FMT
  • Gut
  • Microbiota


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