Impact of Short-Term Intake of Red Wine and Grape Polyphenol Extract on the Human Metabolome

D.M. Jacobs, J.C. Fuhrmann, F.A. van Dorsten, D. Rein, S. Peters, E.J.J. van Velzen, B. Hollebrands, R. Draijer, J.P.M. van Duynhoven, U. Garczarek

Research output: Contribution to journalArticleAcademicpeer-review

61 Citations (Scopus)

Abstract

Red wine and grape polyphenols are considered to promote cardiovascular health and are involved in multiple biological functions. Their overall impact on the human metabolome is not known. Therefore, exogenous and endogenous metabolic effects were determined in fasting plasma and 24 h urine from healthy male adults consuming a mix of red wine and grape juice extracts (WGM) for 4 days in a placebo-controlled, crossover study. Syringic acid, 3-hydroxyhippuric acid, pyrogallol, 3-hydroxyphenylacetic acid, and 3-hydroxyphenylpropionic acid were confirmed as the strongest urinary markers of WGM intake. Overall, WGM had a mild impact on the endogenous metabolism. Most noticeable were changes in several amino acids deriving from tyrosine and tryptophan. Reductions in the microbial metabolites p-cresol sulfate and 3-indoxylsulfuric acid and increases in indole-3-lactic acid and nicotinic acid were observed in urine. In plasma, tyrosine was reduced. The results suggest that short-term intake of WGM altered microbial protein fermentation and/or amino acid metabolism.
Original languageEnglish
Pages (from-to)3078-3085
JournalJournal of Agricultural and Food Chemistry
Volume60
Issue number12
DOIs
Publication statusPublished - 2012

Fingerprint

metabolome
Wine
Metabolome
Vitis
Polyphenols
red wines
Metabolism
Tyrosine
grapes
polyphenols
Urine
Pyrogallol
Plasmas
Amino Acids
Niacin
acids
extracts
Metabolites
Tryptophan
Cross-Over Studies

Keywords

  • black tea
  • phenolic-compounds
  • health
  • gut
  • microbiota
  • biomarkers
  • urine
  • acid
  • microflora
  • modulation

Cite this

Jacobs, D. M., Fuhrmann, J. C., van Dorsten, F. A., Rein, D., Peters, S., van Velzen, E. J. J., ... Garczarek, U. (2012). Impact of Short-Term Intake of Red Wine and Grape Polyphenol Extract on the Human Metabolome. Journal of Agricultural and Food Chemistry, 60(12), 3078-3085. https://doi.org/10.1021/jf2044247
Jacobs, D.M. ; Fuhrmann, J.C. ; van Dorsten, F.A. ; Rein, D. ; Peters, S. ; van Velzen, E.J.J. ; Hollebrands, B. ; Draijer, R. ; van Duynhoven, J.P.M. ; Garczarek, U. / Impact of Short-Term Intake of Red Wine and Grape Polyphenol Extract on the Human Metabolome. In: Journal of Agricultural and Food Chemistry. 2012 ; Vol. 60, No. 12. pp. 3078-3085.
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abstract = "Red wine and grape polyphenols are considered to promote cardiovascular health and are involved in multiple biological functions. Their overall impact on the human metabolome is not known. Therefore, exogenous and endogenous metabolic effects were determined in fasting plasma and 24 h urine from healthy male adults consuming a mix of red wine and grape juice extracts (WGM) for 4 days in a placebo-controlled, crossover study. Syringic acid, 3-hydroxyhippuric acid, pyrogallol, 3-hydroxyphenylacetic acid, and 3-hydroxyphenylpropionic acid were confirmed as the strongest urinary markers of WGM intake. Overall, WGM had a mild impact on the endogenous metabolism. Most noticeable were changes in several amino acids deriving from tyrosine and tryptophan. Reductions in the microbial metabolites p-cresol sulfate and 3-indoxylsulfuric acid and increases in indole-3-lactic acid and nicotinic acid were observed in urine. In plasma, tyrosine was reduced. The results suggest that short-term intake of WGM altered microbial protein fermentation and/or amino acid metabolism.",
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author = "D.M. Jacobs and J.C. Fuhrmann and {van Dorsten}, F.A. and D. Rein and S. Peters and {van Velzen}, E.J.J. and B. Hollebrands and R. Draijer and {van Duynhoven}, J.P.M. and U. Garczarek",
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Jacobs, DM, Fuhrmann, JC, van Dorsten, FA, Rein, D, Peters, S, van Velzen, EJJ, Hollebrands, B, Draijer, R, van Duynhoven, JPM & Garczarek, U 2012, 'Impact of Short-Term Intake of Red Wine and Grape Polyphenol Extract on the Human Metabolome', Journal of Agricultural and Food Chemistry, vol. 60, no. 12, pp. 3078-3085. https://doi.org/10.1021/jf2044247

Impact of Short-Term Intake of Red Wine and Grape Polyphenol Extract on the Human Metabolome. / Jacobs, D.M.; Fuhrmann, J.C.; van Dorsten, F.A.; Rein, D.; Peters, S.; van Velzen, E.J.J.; Hollebrands, B.; Draijer, R.; van Duynhoven, J.P.M.; Garczarek, U.

In: Journal of Agricultural and Food Chemistry, Vol. 60, No. 12, 2012, p. 3078-3085.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Impact of Short-Term Intake of Red Wine and Grape Polyphenol Extract on the Human Metabolome

AU - Jacobs, D.M.

AU - Fuhrmann, J.C.

AU - van Dorsten, F.A.

AU - Rein, D.

AU - Peters, S.

AU - van Velzen, E.J.J.

AU - Hollebrands, B.

AU - Draijer, R.

AU - van Duynhoven, J.P.M.

AU - Garczarek, U.

PY - 2012

Y1 - 2012

N2 - Red wine and grape polyphenols are considered to promote cardiovascular health and are involved in multiple biological functions. Their overall impact on the human metabolome is not known. Therefore, exogenous and endogenous metabolic effects were determined in fasting plasma and 24 h urine from healthy male adults consuming a mix of red wine and grape juice extracts (WGM) for 4 days in a placebo-controlled, crossover study. Syringic acid, 3-hydroxyhippuric acid, pyrogallol, 3-hydroxyphenylacetic acid, and 3-hydroxyphenylpropionic acid were confirmed as the strongest urinary markers of WGM intake. Overall, WGM had a mild impact on the endogenous metabolism. Most noticeable were changes in several amino acids deriving from tyrosine and tryptophan. Reductions in the microbial metabolites p-cresol sulfate and 3-indoxylsulfuric acid and increases in indole-3-lactic acid and nicotinic acid were observed in urine. In plasma, tyrosine was reduced. The results suggest that short-term intake of WGM altered microbial protein fermentation and/or amino acid metabolism.

AB - Red wine and grape polyphenols are considered to promote cardiovascular health and are involved in multiple biological functions. Their overall impact on the human metabolome is not known. Therefore, exogenous and endogenous metabolic effects were determined in fasting plasma and 24 h urine from healthy male adults consuming a mix of red wine and grape juice extracts (WGM) for 4 days in a placebo-controlled, crossover study. Syringic acid, 3-hydroxyhippuric acid, pyrogallol, 3-hydroxyphenylacetic acid, and 3-hydroxyphenylpropionic acid were confirmed as the strongest urinary markers of WGM intake. Overall, WGM had a mild impact on the endogenous metabolism. Most noticeable were changes in several amino acids deriving from tyrosine and tryptophan. Reductions in the microbial metabolites p-cresol sulfate and 3-indoxylsulfuric acid and increases in indole-3-lactic acid and nicotinic acid were observed in urine. In plasma, tyrosine was reduced. The results suggest that short-term intake of WGM altered microbial protein fermentation and/or amino acid metabolism.

KW - black tea

KW - phenolic-compounds

KW - health

KW - gut

KW - microbiota

KW - biomarkers

KW - urine

KW - acid

KW - microflora

KW - modulation

U2 - 10.1021/jf2044247

DO - 10.1021/jf2044247

M3 - Article

VL - 60

SP - 3078

EP - 3085

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 12

ER -