Impact of CFA and dietary protein supply on acute phase responses and nitrogen retention in pigs

E. van de Hoek, P. Sakkas, J.J.G.C. van den Borne, W.J.J. Gerrits, C.M.C. van der Peet-Schwering, H. van Beers, A.J.M. Jansman

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademicpeer-review

Abstract

During immune system activation, an increased competition occurs between amino acids (AA) for body protein deposition and for immune system functioning (Klasing and Johnstone, 1991; Sandberg et al., 2007). The production of acute phase proteins (APP) has been suggested to increase the demand for especially aromatic AA (Reeds et al., 1994). When muscle protein is mobilized to supply AA for APP production, this leads to an imbalance in AA available for body protein deposition, as the AA composition of APP differs largely from the composition of muscle protein (Reeds et al., 1994). As a consequence, increased AA oxidation and N loss via urine occur. It is hypothesized that the competition between AA increases when dietary protein supply is reduced. In addition, there is increasing evidence that the dietary protein or AA supply can modulate the inflammatory response during immune system activation (Grimble, 2001; Calder and Yaqoob, 2012). The aim of the present study was to quantify the interaction between acute phase protein (APP) responses, induced by immune system activation, and dietary protein supply on nitrogen (N) metabolism.
Original languageEnglish
Title of host publicationProceedings of the 4th International Symposium on Energy and Protein Metabolism and Nutrition, 9-12 September 2013, Sacramento, California, USA
EditorsJ.W. Oltjen, E. Kebreab, H. Lapierre
Place of PublicationWageningen
PublisherWageningen Academic Publishers
Pages367-368
Volume134
ISBN (Print)9789086862276
DOIs
Publication statusPublished - 2013
Event4th International Symposium on Energy and Protein Metabolism and Nutrition, Sacramento, California, USA -
Duration: 9 Sep 201312 Sep 2013

Conference

Conference4th International Symposium on Energy and Protein Metabolism and Nutrition, Sacramento, California, USA
Period9/09/1312/09/13

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