Immunomodulation by food: promising concept for mitigating allergic disease?

Research output: Contribution to journalReview articleAcademicpeer-review

42 Citations (Scopus)

Abstract

The importance of a properly functioning and well-balanced immune system for maintaining health has become strikingly evident over the past decades. Roughly since World War II, there has been an apparent decrease in the prevalence of “traditional” infectious diseases, with a concomitant increase in immune-related disorders, such as allergies. Causally, a relationship with changes in life-style-related factors such as the increasing use of hygienic practices seems likely. Diet and nutrition can affect the functioning of various immune parameters. This concept can be utilised in attempts to prevent or mitigate allergic reactions via the development of targeted food products or ingredients. This review describes recent findings with respect to food products and ingredients that show potential in this respect, with special emphasis on pro- and prebiotics, ß-glucans and fungal immunomodulatory proteins. What all of these approaches have in common is that they appear to strengthen Th1-mediated immunity, thus possibly restoring defective immune maturation due to overly hygienic living conditions: a little bit of dirt does not seem bad!
Original languageEnglish
Pages (from-to)37-45
JournalAnalytical and Bioanalytical Chemistry
Volume395
Issue number1
DOIs
Publication statusPublished - 2009

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Immunomodulation
Nutrition
Hypersensitivity
Allergies
Food
Prebiotics
World War II
Fungal Proteins
Glucans
Immune system
Social Conditions
Immune System Diseases
Probiotics
Communicable Diseases
Life Style
Immune System
Immunity
Health
Diet

Keywords

  • placebo-controlled trial
  • functional foods
  • immune function
  • beta-glucan
  • aureobasidium-pullulans
  • flammulina-velutipes
  • cytokine production
  • dietary modulation
  • metabolic syndrome
  • mononuclear-cells

Cite this

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title = "Immunomodulation by food: promising concept for mitigating allergic disease?",
abstract = "The importance of a properly functioning and well-balanced immune system for maintaining health has become strikingly evident over the past decades. Roughly since World War II, there has been an apparent decrease in the prevalence of “traditional” infectious diseases, with a concomitant increase in immune-related disorders, such as allergies. Causally, a relationship with changes in life-style-related factors such as the increasing use of hygienic practices seems likely. Diet and nutrition can affect the functioning of various immune parameters. This concept can be utilised in attempts to prevent or mitigate allergic reactions via the development of targeted food products or ingredients. This review describes recent findings with respect to food products and ingredients that show potential in this respect, with special emphasis on pro- and prebiotics, {\ss}-glucans and fungal immunomodulatory proteins. What all of these approaches have in common is that they appear to strengthen Th1-mediated immunity, thus possibly restoring defective immune maturation due to overly hygienic living conditions: a little bit of dirt does not seem bad!",
keywords = "placebo-controlled trial, functional foods, immune function, beta-glucan, aureobasidium-pullulans, flammulina-velutipes, cytokine production, dietary modulation, metabolic syndrome, mononuclear-cells",
author = "H.J. Wichers",
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Immunomodulation by food: promising concept for mitigating allergic disease? / Wichers, H.J.

In: Analytical and Bioanalytical Chemistry, Vol. 395, No. 1, 2009, p. 37-45.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Immunomodulation by food: promising concept for mitigating allergic disease?

AU - Wichers, H.J.

PY - 2009

Y1 - 2009

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AB - The importance of a properly functioning and well-balanced immune system for maintaining health has become strikingly evident over the past decades. Roughly since World War II, there has been an apparent decrease in the prevalence of “traditional” infectious diseases, with a concomitant increase in immune-related disorders, such as allergies. Causally, a relationship with changes in life-style-related factors such as the increasing use of hygienic practices seems likely. Diet and nutrition can affect the functioning of various immune parameters. This concept can be utilised in attempts to prevent or mitigate allergic reactions via the development of targeted food products or ingredients. This review describes recent findings with respect to food products and ingredients that show potential in this respect, with special emphasis on pro- and prebiotics, ß-glucans and fungal immunomodulatory proteins. What all of these approaches have in common is that they appear to strengthen Th1-mediated immunity, thus possibly restoring defective immune maturation due to overly hygienic living conditions: a little bit of dirt does not seem bad!

KW - placebo-controlled trial

KW - functional foods

KW - immune function

KW - beta-glucan

KW - aureobasidium-pullulans

KW - flammulina-velutipes

KW - cytokine production

KW - dietary modulation

KW - metabolic syndrome

KW - mononuclear-cells

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JO - Analytical and Bioanalytical Chemistry

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SN - 1618-2642

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